UniProt Accession

 DAPD_ECOLI; P0A9D8; P03948 

Genbank Protein ID

 K02970; U70214; U00096; AP009048; Z21842 

Genbank Nucleotide ID

 AAA23667.1; AAB08595.1; AAC73277.1; BAB96742.1; CAA79888.1 

Protein Name

 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase 

Protein Synonyms/Alias

 Tetrahydrodipicolinate N-succinyltransferase; THDP succinyltransferase; THP succinyltransferase; Tetrahydropicolinate succinylase 

Gene Name

 dapD 

Gene Synonyms/Alias

 b0166; JW0161 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
48	GALRVAEKIDGQWVT	acetylation	[1]
60	WVTHQWLKKAVLLSF	acetylation	[1]
61	VTHQWLKKAVLLSFR	acetylation	[1, 2]
85	AESRYFDKVPMKFAD	acetylation	[1, 3]
89	YFDKVPMKFADYDEA	acetylation	[1]
100	YDEARFQKEGFRVVP	acetylation	[1, 3]
100	YDEARFQKEGFRVVP	pupylation	[4]
241	VSGNLPSKDGKYSLY	acetylation	[1]
244	NLPSKDGKYSLYCAV	acetylation	[1]
254	LYCAVIVKKVDAKTR	acetylation	[1]
263	VDAKTRGKVGINELL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] The diversity of lysine-acetylated proteins in Escherichia coli.
 Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG.
 J Microbiol Biotechnol. 2008 Sep;18(9):1529-36. [PMID: 18852508]
 [4] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222] 

Functional Description

  

Sequence Annotation

 BINDING 104 104 Substrate (By similarity).
 BINDING 141 141 Substrate (By similarity).  

Keyword

 Acyltransferase; Amino-acid biosynthesis; Complete proteome; Cytoplasm; Diaminopimelate biosynthesis; Direct protein sequencing; Lysine biosynthesis; Reference proteome; Repeat; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008666; F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity; IDA:EcoCyc.
 GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP.
 GO:0009085; P:lysine biosynthetic process; IDA:EcoCyc.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP. 

Interpro

 IPR005664; DapD_Trfase_Hexpep_rpt_fam.
 IPR001451; Hexapep_transf.
 IPR018357; Hexapep_transf_CS.
 IPR023180; THP_succinylTrfase_dom1.
 IPR011004; Trimer_LpxA-like. 

Pfam

 PF00132; Hexapep 

SMART

  

PROSITE

 PS00101; HEXAPEP_TRANSFERASES 

PRINTS