UniProt Accession

 AHSA1_MOUSE; Q8BK64; Q8R3E6 

Genbank Protein ID

 AK076069; BC023857; BC025552 

Genbank Nucleotide ID

 BAC36160.1; AAH23857.1; AAH25552.1 

Protein Name

 Activator of 90 kDa heat shock protein ATPase homolog 1 

Protein Synonyms/Alias

 AHA1 

Gene Name

 Ahsa1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKWGEGDPR	acetylation	[1, 2]
194	KAKSAPSKSQAKPVG	acetylation	[2]
212	PTCKITLKETFLTSP	acetylation	[3]
249	LEADRGGKFHMVDGN	acetylation	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Co-chaperone that stimulates HSP90 ATPase activity. May affect a step in the endoplasmic reticulum to Golgi trafficking (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 3 3 N6-acetyllysine (By similarity).
 MOD_RES 193 193 Phosphoserine (By similarity).
 MOD_RES 212 212 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Chaperone; Complete proteome; Cytoplasm; Endoplasmic reticulum; Phosphoprotein; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 338 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0001671; F:ATPase activator activity; ISS:UniProtKB.
 GO:0006457; P:protein folding; ISS:UniProtKB.
 GO:0006950; P:response to stress; ISS:UniProtKB. 

Interpro

 IPR013538; Activator_of_Hsp90_ATPase.
 IPR015310; AHSA1_N.
 IPR023393; START-like_dom. 

Pfam

 PF09229; Aha1_N
 PF08327; AHSA1 

SMART

 SM01000; Aha1_N 

PROSITE

  

PRINTS