UniProt Accession

 ADPRM_HUMAN; Q3LIE5; A8K9B4; D3DTS4; Q9BVD4; Q9NRU8 

Genbank Protein ID

 AB073393; AK292629; CH471108; CH471108; BC001294; BC070155; AF168715 

Genbank Nucleotide ID

 BAE45723.1; BAF85318.1; EAW89995.1; EAW89996.1; AAH01294.1; AAH70155.1; AAF87317.1 

Protein Name

 Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase 

Protein Synonyms/Alias

 ADPRibase-Mn; CDP-choline phosphohydrolase 

Gene Name

 ADPRM 

Gene Synonyms/Alias

 C17orf48; MDS006; Nbla03831 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
125	REYLTHSKLNTKFLE	ubiquitination	[1]
129	THSKLNTKFLEDQIV	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). 

Sequence Annotation

 METAL 25 25 Zinc 1 (By similarity).
 METAL 27 27 Zinc 1 (By similarity).
 METAL 74 74 Zinc 1 (By similarity).
 METAL 74 74 Zinc 2 (By similarity).
 METAL 110 110 Zinc 2 (By similarity).
 METAL 241 241 Zinc 2 (By similarity).
 METAL 278 278 Zinc 2 (By similarity).
 METAL 280 280 Zinc 1 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Metal-binding; Polymorphism; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 342 AA 

Protein Sequence

Gene Ontology

 GO:0047631; F:ADP-ribose diphosphatase activity; IEA:EC.
 GO:0047734; F:CDP-glycerol diphosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR004843; Metallo_PEstase_dom. 

Pfam

 PF00149; Metallophos 

SMART

  

PROSITE

  

PRINTS