UniProt Accession

 CTDS2_HUMAN; O14595; A8K5H4; Q53ZR2; Q6NZY3; Q9UEX1 

Genbank Protein ID

 AF000152; AY279531; AF022231; AK291289; CH471054; BC065920 

Genbank Nucleotide ID

 AAB71816.1; AAP34399.1; AAD09331.1; BAF83978.1; EAW97083.1; AAH65920.1 

Protein Name

 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 

Protein Synonyms/Alias

 Nuclear LIM interactor-interacting factor 2; NLI-interacting factor 2; Protein OS-4; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2; SCP2 

Gene Name

 CTDSP2 

Gene Synonyms/Alias

 NIF2; OS4; SCP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	EDALVLTKQGLVSKS	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. 

Sequence Annotation

 DOMAIN 97 255 FCP1 homology.
 ACT_SITE 107 107 4-aspartylphosphate intermediate (By
 ACT_SITE 109 109 Proton donor (By similarity).
 METAL 107 107 Magnesium.
 METAL 109 109 Magnesium; via carbonyl oxygen.
 METAL 218 218 Magnesium.  

Keyword

 3D-structure; Complete proteome; Hydrolase; Metal-binding; Nucleus; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 271 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0008420; F:CTD phosphatase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.
 GO:0006470; P:protein dephosphorylation; IDA:UniProtKB. 

Interpro

 IPR011948; Dullard_phosphatase.
 IPR023214; HAD-like_dom.
 IPR004274; NIF. 

Pfam

 PF03031; NIF 

SMART

 SM00577; CPDc 

PROSITE

 PS50969; FCP1 

PRINTS