| Tag | Content |
|---|
| CPLM ID | CPLM-023488 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transient receptor potential cation channel subfamily V member 2 |
Protein Synonyms/Alias | TrpV2; Growth factor-regulated calcium channel; GRC; Osm-9-like TRP channel 2; OTRPC2 |
Gene Name | Trpv2 |
Gene Synonyms/Alias | Grc |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 730 | GAGITGYKKNPTSKP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. |
Sequence Annotation | REPEAT 68 110 ANK 1.
REPEAT 111 157 ANK 2.
REPEAT 158 203 ANK 3.
REPEAT 204 239 ANK 4.
REPEAT 240 288 ANK 5.
REPEAT 289 315 ANK 6.
REGION 1 385 Required for interaction with SLC50A1 (By
MOD_RES 15 15 Phosphoserine.
MOD_RES 47 47 Phosphoserine.
MOD_RES 755 755 Phosphoserine.
CARBOHYD 567 567 N-linked (GlcNAc...) (Potential). |
Keyword | ANK repeat; Calcium; Calcium channel; Calcium transport; Cell membrane; Complete proteome; Cytoplasm; Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 756 AA |
Protein Sequence | MTSASNPPAF RLETSDGDEE GSAEVNKGKN EPPPMESPFQ GEDRNFSPQI KVNLNYRKGL 60
GPSQQDPNRF DRDRLFSVVS RGVPEELTGL LEYLRRTSKY LTDSAYTEGS TGKTCLMKAV 120
LNLQDGVNAC ILPLLQIDRD SGNPQPLVNA QCTDEFYRGH SALHIAIEKR SLWCVKLLVE 180
NGANVHIRAC GRFFQKHQGT CFYFGELPLS LAACTKQWDV VTYLLENPHQ PASLEATDSL 240
GNTVLHALVM IADNSPENSA LVIHMYDSLL QMGARLCPTV QLEDICNHQG LTPLKLAAKE 300
GKIEIFRHIL QREFSGLYQP LSRKFTEWCY GPVRVSLYDL SSVDSWEKNS VLEIIAFHCK 360
SPHRHRMVVL EPLNKLLQEK WDRLIPRFFF NFACYLVYMI IFTIVAYHQP SLEQPAIPSS 420
KATFGDSMLL LGHILILLGG IYLLLGQLWY FWRRRLFIWI SFMDSYFEIL FLVQALLTVL 480
SQVLRFVETE WYLPLLVSSL VLGWLNLLYY TRGFQHTGIY SVMIQKVILR DLLRFLLVYL 540
VFLFGFAVAL VSLSREARSP KAPEDSNTTV TEKPTLGQEE EPVPYGGILD ASLELFKFTI 600
GMGELAFQEQ LRFRGVVLLL LLAYVLLTYV LLLNMLIALM SETVNSVATD SWSIWKLQKA 660
ISVLEMENGY WWCRRKRHRA GRLLKVGTKG DGIPDERWCF RVEEVNWAAW EKTLPTLSED 720
PSGAGITGYK KNPTSKPGKN SASEEDHLPL QVLQSH 756 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |