UniProt Accession

 CASP7_HUMAN; P55210; B4DQU7; B5BU45; D3DRB8; Q13364; Q53YD5; Q5SVL0; Q5SVL3; Q96BA0 

Genbank Protein ID

 U37448; U37449; U39613; U40281; U67319; U67320; U67206; BT006683; AB451281; AB451413; AK298964; AL592546; AL627395; AL592546; AL627395; AL627395; AL592546; AL627395; AL592546; CH471066; CH471066; CH471066; CH471066; CH471066; BC015799 

Genbank Nucleotide ID

 AAC50303.1; AAC50304.1; AAC50346.1; AAC50352.1; AAC51152.1; AAC51153.1; AAF21460.1; AAP35329.1; BAG70095.1; BAG70227.1; BAG61059.1; CAI12638.1; CAI12638.1; CAI12639.1; CAI12639.1; CAI16004.1; CAI16004.1; CAI16005.1; CAI16005.1; EAW49494.1; EAW49495.1; EAW49498.1; EAW49496.1; EAW49497.1; AAH15799.1 

Protein Name

 Caspase-7 

Protein Synonyms/Alias

 CASP-7; Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3; Caspase-7 subunit p20; Caspase-7 subunit p11 

Gene Name

 CASP7 

Gene Synonyms/Alias

 MCH3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
132	KDAEALFKCFRSLGF	ubiquitination	[1]
193	KDGVTPIKDLTAHFR	ubiquitination	[2]
205	HFRGDRCKTLLEKPK	ubiquitination	[2]
319	DPHFHEKKQIPCVVS	ubiquitination	[2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. 

Sequence Annotation

 ACT_SITE 144 144 By similarity.
 ACT_SITE 186 186
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 16 16 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Protease; Reference proteome; Thiol protease; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0004190; F:aspartic-type endopeptidase activity; IEA:Compara.
 GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome.
 GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; TAS:Reactome.
 GO:0006921; P:cellular component disassembly involved in execution phase of apoptosis; TAS:Reactome.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:Reactome.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0016485; P:protein processing; IEA:Compara.
 GO:0006508; P:proteolysis; IDA:UniProtKB.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0009411; P:response to UV; IEA:Compara. 

Interpro

 IPR015471; Casp7.
 IPR011600; Pept_C14_cat.
 IPR001309; Pept_C14_ICE_p20.
 IPR016129; Pept_C14_ICE_p20_AS.
 IPR002138; Pept_C14_p10.
 IPR002398; Pept_C14_p45.
 IPR015917; Pept_C14_p45_core. 

Pfam

 PF00656; Peptidase_C14 

SMART

 SM00115; CASc 

PROSITE

 PS01122; CASPASE_CYS
 PS01121; CASPASE_HIS
 PS50207; CASPASE_P10
 PS50208; CASPASE_P20 

PRINTS

 PR00376; IL1BCENZYME.