CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025875
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MKIAA4216 protein 
Protein Synonyms/Alias
  
Gene Name
 Ube3a 
Gene Synonyms/Alias
 mKIAA4216 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
64RMKRAAAKHLIERYYubiquitination[1]
105DNNAAAIKALELYKIubiquitination[1]
111IKALELYKINAKLCDubiquitination[1]
124CDPHPSKKGASSAYLubiquitination[1]
135SAYLENSKGASNNSEubiquitination[1]
154KKEGKDFKDVIYLTEubiquitination[1]
226KDEDEKEKAACSAAAubiquitination[1]
346LFCKAMCKLPLEAQGubiquitination[1]
354LPLEAQGKLIRLWSKubiquitination[1]
361KLIRLWSKYSADQIRubiquitination[1]
381FQQLITYKVISNEFNubiquitination[1]
404DAIVAASKCLKMVYYubiquitination[1]
452GDERRNKKGPRVDPLubiquitination[1]
466LETELGVKTLDCRKPubiquitination[1]
499DKDYTFFKVETENKFubiquitination[1]
583MENPADLKKQLYVEFubiquitination[1]
584ENPADLKKQLYVEFEubiquitination[1]
733DLKENGDKIPITNENubiquitination[1]
742PITNENRKEFVNLYSubiquitination[1]
755YSDYILNKSVEKQFKubiquitination[1]
853APVGGLGKLKMIIAKubiquitination[1]
855VGGLGKLKMIIAKNGubiquitination[1]
860KLKMIIAKNGPDTERubiquitination[1]
895KLKERLLKAITYAKGubiquitination[1]
901LKAITYAKGFGML**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Ligase; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 906 AA 
Protein Sequence
DPAVAPAKGN EAVAGGGGGR GRQGPVRRPQ LRGPQPTRGG EDRSPGESQS EDIEASRMKR 60
AAAKHLIERY YHQLTEGCGN EACTNEFCAS CPTFLRMDNN AAAIKALELY KINAKLCDPH 120
PSKKGASSAY LENSKGASNN SEIKMNKKEG KDFKDVIYLT EEKVYEIYEF CRESEDYSPL 180
IRVIGRIFSS AEALVLSFRK VKQHTKEELK SLQEKDEDKD EDEKEKAACS AAAMEEDSEA 240
SSSRMGDSSQ GDNNVQKLGP DDVTVDIDAI RRVYSSLLAN EKLETAFLNA LVYLSPNVEC 300
DLTYHNVYTR DPNYLNLFII VMENSNLHSP EYLEMALPLF CKAMCKLPLE AQGKLIRLWS 360
KYSADQIRRM METFQQLITY KVISNEFNSR NLVNDDDAIV AASKCLKMVY YANVVGGDVD 420
TNHNEEDDEE PIPESSELTL QELLGDERRN KKGPRVDPLE TELGVKTLDC RKPLISFEEF 480
INEPLNDVLE MDKDYTFFKV ETENKFSFMT CPFILNAVTK NLGLYYDNRI RMYSERRITV 540
LYSLVQGQQL NPYLRLKVRR DHIIDDALVR LEMIAMENPA DLKKQLYVEF EGEQGVDEGG 600
VSKEFFQLVV EEIFNPDIGM FTYDEATKLF WFNPSSFETE GQFTLIGIVL GLAIYNNCIL 660
DVHFPMVVYR KLMGKKGTFR DLGDSHPVLY QSLKDLLEYE GSVEDDMMIT FQISQTDLFG 720
NPMMYDLKEN GDKIPITNEN RKEFVNLYSD YILNKSVEKQ FKAFRRGFHM VTNESPLKYL 780
FRPEEIELLI CGSRNLDFQA LEETTEYDGG YTRESVVIRE FWEIVHSFTD EQKRLFLQFT 840
TGTDRAPVGG LGKLKMIIAK NGPDTERLPT SHTCFNVLLL PEYSSKEKLK ERLLKAITYA 900
KGFGML 906 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0030521; P:androgen receptor signaling pathway; IPI:MGI.
 GO:0001541; P:ovarian follicle development; IMP:MGI.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0060736; P:prostate gland growth; IMP:MGI.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
 GO:0035037; P:sperm entry; IMP:MGI. 
Interpro
 IPR000569; HECT.
 IPR017134; Ubiquitin-protein_ligase_E6-AP. 
Pfam
 PF00632; HECT 
SMART
 SM00119; HECTc 
PROSITE
 PS50237; HECT 
PRINTS