CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004834
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Beta-hexosaminidase subunit beta 
Protein Synonyms/Alias
 Beta-N-acetylhexosaminidase subunit beta; Hexosaminidase subunit B; N-acetyl-beta-glucosaminidase subunit beta 
Gene Name
 Hexb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
378LEIISSLKKNSIVWQacetylation[1]
535GYCNYENKI******acetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. 
Sequence Annotation
 ACT_SITE 334 334 Proton donor (By similarity).
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
 CARBOHYD 306 306 N-linked (GlcNAc...) (Potential).
 DISULFID 70 116 By similarity.
 DISULFID 288 339 By similarity.
 DISULFID 513 530 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Glycosidase; Hydrolase; Lysosome; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 536 AA 
Protein Sequence
MPQSPRSAPG LLLLQALVSL VSLALVAPAR LQPALWPFPR SVQMFPRLLY ISAEDFSIDH 60
SPNSTAGPSC SLLQEAFRRY YNYVFGFYKR HHGPARFRAE PQLQKLLVSI TLESECESFP 120
SLSSDETYSL LVQEPVAVLK ANSVWGALRG LETFSQLVYQ DSFGTFTINE SSIADSPRFP 180
HRGILIDTSR HFLPVKTILK TLDAMAFNKF NVLHWHIVDD QSFPYQSTTF PELSNKGSYS 240
LSHVYTPNDV RMVLEYARLR GIRVIPEFDT PGHTQSWGKG QKNLLTPCYN QKTKTQVFGP 300
VDPTVNTTYA FFNTFFKEIS SVFPDQFIHL GGDEVEFQCW ASNPNIQGFM KRKGFGSDFR 360
RLESFYIKKI LEIISSLKKN SIVWQEVFDD KVELQPGTVV EVWKSEHYSY ELKQVTGSGF 420
PAILSAPWYL DLISYGQDWK NYYKVEPLNF EGSEKQKQLV IGGEACLWGE FVDATNLTPR 480
LWPRASAVGE RLWSPKTVTD LENAYKRLAV HRCRMVSRGI AAQPLYTGYC NYENKI 536 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IDA:MGI.
 GO:0005764; C:lysosome; IDA:MGI.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0004563; F:beta-N-acetylhexosaminidase activity; IDA:MGI.
 GO:0042803; F:protein homodimerization activity; IDA:MGI.
 GO:0043615; P:astrocyte cell migration; IMP:UniProtKB.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0044267; P:cellular protein metabolic process; IMP:MGI.
 GO:0006689; P:ganglioside catabolic process; IMP:MGI.
 GO:0030203; P:glycosaminoglycan metabolic process; IGI:MGI.
 GO:0019915; P:lipid storage; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0007040; P:lysosome organization; IMP:MGI.
 GO:0008049; P:male courtship behavior; IMP:MGI.
 GO:0042552; P:myelination; IGI:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.
 GO:0009313; P:oligosaccharide catabolic process; IMP:MGI.
 GO:0048477; P:oogenesis; IMP:MGI.
 GO:0007341; P:penetration of zona pellucida; IMP:MGI.
 GO:0008654; P:phospholipid biosynthetic process; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0008360; P:regulation of cell shape; IMP:UniProtKB.
 GO:0007605; P:sensory perception of sound; IGI:MGI.
 GO:0001501; P:skeletal system development; IGI:MGI. 
Interpro
 IPR025705; Beta_hexosaminidase_sua/sub.
 IPR015883; Glyco_hydro_20_cat-core.
 IPR015882; Glyco_hydro_20b.
 IPR013781; Glyco_hydro_catalytic_dom.
 IPR017853; Glycoside_hydrolase_SF. 
Pfam
 PF00728; Glyco_hydro_20
 PF02838; Glyco_hydro_20b 
SMART
  
PROSITE
  
PRINTS
 PR00738; GLHYDRLASE20.