UniProt Accession

 KCD12_HUMAN; Q96CX2 

Genbank Protein ID

 AF359381; BC013764 

Genbank Nucleotide ID

 AAQ15187.1; AAH13764.1 

Protein Name

 BTB/POZ domain-containing protein KCTD12 

Protein Synonyms/Alias

 Pfetin; Predominantly fetal expressed T1 domain 

Gene Name

 KCTD12 

Gene Synonyms/Alias

 C13orf2; KIAA1778; PFET1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
229	RDAQADAKFRRVARI	acetylation	[1]
229	RDAQADAKFRRVARI	ubiquitination	[2, 3]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity). 

Sequence Annotation

 MOD_RES 119 119 Phosphotyrosine (By similarity).
 MOD_RES 185 185 Phosphoserine.
 MOD_RES 187 187 Phosphoserine (By similarity).
 MOD_RES 196 196 Phosphothreonine (By similarity).  

Keyword

 Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 325 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0043235; C:receptor complex; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:Compara. 

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR003131; T1-type_BTB. 

Pfam

 PF02214; K_tetra 

SMART

 SM00225; BTB 

PROSITE

  

PRINTS