UniProt Accession

 AQP1_MOUSE; Q02013; Q542P1; Q91VY8 

Genbank Protein ID

 L02914; AK081886; AK086688; AK157333; AK158226; AK158389; AK171627; AK172361; BC007125 

Genbank Nucleotide ID

 AAB53928.1; BAC38360.1; BAC39719.1; BAE34051.1; BAE34412.1; BAE34482.1; BAE42573.1; BAE42966.1; AAH07125.1 

Protein Name

 Aquaporin-1 

Protein Synonyms/Alias

 AQP-1; Aquaporin-CHIP; Delayed early response protein 2; DER2; Water channel protein for red blood cells and kidney proximal tubule 

Gene Name

 Aqp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
243	SDFTDRMKVWTSGQV	ubiquitination	[1]
267	INSRVEMKPK*****	acetylation	[2]
267	INSRVEMKPK*****	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. 

Sequence Annotation

 MOTIF 76 78 NPA 1.
 MOTIF 192 194 NPA 2.
 MOD_RES 246 246 Phosphothreonine.
 MOD_RES 247 247 Phosphoserine.
 MOD_RES 262 262 Phosphoserine.
 CARBOHYD 205 205 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0030424; C:axon; IDA:MGI.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0009925; C:basal plasma membrane; ISS:UniProtKB.
 GO:0031526; C:brush border membrane; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0070062; C:extracellular vesicular exosome; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0032809; C:neuronal cell body membrane; IEA:Compara.
 GO:0031965; C:nuclear membrane; ISS:UniProtKB.
 GO:0042383; C:sarcolemma; ISS:UniProtKB.
 GO:0020003; C:symbiont-containing vacuole; IDA:UniProtKB.
 GO:0051739; F:ammonia transmembrane transporter activity; ISS:UniProtKB.
 GO:0035379; F:carbon dioxide transmembrane transporter activity; ISS:UniProtKB.
 GO:0015168; F:glycerol transmembrane transporter activity; ISS:UniProtKB.
 GO:0005223; F:intracellular cGMP activated cation channel activity; ISS:UniProtKB.
 GO:0030184; F:nitric oxide transmembrane transporter activity; ISS:UniProtKB.
 GO:0005267; F:potassium channel activity; ISS:UniProtKB.
 GO:0015250; F:water channel activity; ISS:UniProtKB.
 GO:0015696; P:ammonium transport; ISS:UniProtKB.
 GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.
 GO:0006884; P:cell volume homeostasis; ISS:UniProtKB.
 GO:0071474; P:cellular hyperosmotic response; ISS:UniProtKB.
 GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.
 GO:0071280; P:cellular response to copper ion; ISS:UniProtKB.
 GO:0071549; P:cellular response to dexamethasone stimulus; ISS:UniProtKB.
 GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.
 GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.
 GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.
 GO:0071288; P:cellular response to mercury ion; ISS:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
 GO:0071472; P:cellular response to salt stress; ISS:UniProtKB.
 GO:0034644; P:cellular response to UV; ISS:UniProtKB.
 GO:0006182; P:cGMP biosynthetic process; ISS:UniProtKB.
 GO:0051458; P:corticotropin secretion; IMP:MGI.
 GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; ISS:UniProtKB.
 GO:0003094; P:glomerular filtration; IMP:MGI.
 GO:0042538; P:hyperosmotic salinity response; IEA:Compara.
 GO:0021670; P:lateral ventricle development; IEP:UniProtKB.
 GO:0044241; P:lipid digestion; IMP:MGI.
 GO:0085018; P:maintenance of symbiont-containing vacuole by host; IMP:UniProtKB.
 GO:0072220; P:metanephric descending thin limb development; IEP:UniProtKB.
 GO:0072239; P:metanephric glomerulus vasculature development; IEP:UniProtKB.
 GO:0072232; P:metanephric proximal convoluted tubule segment 2 development; IEP:UniProtKB.
 GO:0072230; P:metanephric proximal straight tubule development; IEP:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
 GO:0030335; P:positive regulation of cell migration; IMP:MGI.
 GO:0010634; P:positive regulation of epithelial cell migration; IEA:Compara.
 GO:0048146; P:positive regulation of fibroblast proliferation; ISS:UniProtKB.
 GO:0010592; P:positive regulation of lamellipodium assembly; IEA:Compara.
 GO:0046878; P:positive regulation of saliva secretion; ISS:UniProtKB.
 GO:0070295; P:renal water absorption; IMP:MGI.
 GO:0042493; P:response to drug; ISS:UniProtKB.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0033363; P:secretory granule organization; IMP:MGI.
 GO:0019233; P:sensory perception of pain; IMP:MGI.
 GO:0035377; P:transepithelial water transport; ISS:UniProtKB.
 GO:0042060; P:wound healing; IMP:MGI. 

Interpro

 IPR023271; Aquaporin-like.
 IPR023274; Aquaporin_1.
 IPR000425; MIP.
 IPR022357; MIP_CS. 

Pfam

 PF00230; MIP 

SMART

  

PROSITE

 PS00221; MIP 

PRINTS

 PR02013; AQUAPORIN1.
 PR00783; MINTRINSICP.