CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044741
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein SON 
Protein Synonyms/Alias
  
Gene Name
 SON 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16FRSFVVSKFREIQQEacetylation[1, 2]
16FRSFVVSKFREIQQEubiquitination[3, 4, 5, 6]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 454 AA 
Protein Sequence
MATNIEQIFR SFVVSKFREI QQELSSGRNE GQLNGETNTP IEGNQAGDAA ASARSLPNEE 60
IVQKIEEVLS GVLDTELRYK PDKAQLLEIA KANAAAMCAK AGVPLPPNLK PAPPPTIEEK 120
VAKKSGGATI EELTEKCKQI AQSKEDDDVI VNKPHVSDEE EEEPPFYHHP FKLSEPKPIF 180
FNLNIAAAKP TPPKSQVTLT KEFPVSSGSQ HRKKEADSVY GEWVPVEKNG EENKDDDNVF 240
SSNLPSEPVD ISTAMSERAL AQKRLSENAF DLEAMSMLNR AQERIDAWAQ LNSIPGQFTG 300
STGVQVLTQE QLANTGAQAW IKKDQFLRAA PVTGGMGAVL MRKMGWREGE GLGKNKEGNK 360
EPILVDFKTD RKGLVAVGER AQKRSGNFSA AMKDLSGKHP VSALMEICNK RRWQPPEFLL 420
VHDSGPDHRK HFLFRVLRNG ALTRPNCMFF LNRY 454 
Gene Ontology
 GO:0003725; F:double-stranded RNA binding; IEA:InterPro. 
Interpro
 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom.
 IPR000467; G_patch_dom. 
Pfam
 PF01585; G-patch 
SMART
 SM00443; G_patch 
PROSITE
 PS50137; DS_RBD
 PS50174; G_PATCH 
PRINTS