| Tag | Content |
|---|
| CPLM ID | CPLM-021054 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier organic anion transporter family member 2A1 |
Protein Synonyms/Alias | Prostaglandin transporter; PGT; Solute carrier family 21 member 2 |
Gene Name | Slco2a1 |
Gene Synonyms/Alias | Oatp2a1; Slc21a2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 297 | VIAEETMKMEEDKSR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. |
Sequence Annotation | DOMAIN 437 495 Kazal-like.
CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
CARBOHYD 477 477 N-linked (GlcNAc...) (Potential).
CARBOHYD 490 490 N-linked (GlcNAc...) (Potential).
DISULFID 443 469 By similarity.
DISULFID 447 458 By similarity.
DISULFID 449 473 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 643 AA |
Protein Sequence | MGLLPKPGAR QGSGTSSVPA RRCSRSVFNN IKVFVLCHGL LQLCQLLYSA YFKSSLTTIE 60
KRFGLSSSSS GLISSLNEIS NAILIIFVSY FGSRVNRPRM IGIGGLLLAA GAFVLTLPHF 120
LSEPYQYAST TAGNSSHFQT DLCQKHLPGL LPSKCHSTVP DTQKETSSMW SLMVVAQLLA 180
GVGTVPIQPF GISYVDDFAE PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD 240
TATVNLSPGD PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV IAEETMKMEE 300
DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK FLEKQYDASA 360
AYANLLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA ATIMTISIIL CAPLFFMGCS 420
TPAVAEVYPP STPSSIHPQP PACRRDCLCP DSVFHPVCGD NGVEYLSPCH AGCSSLNVSS 480
AASKQPIYLN CSCVTGGSAS AKTGSCPTSC AQLLLPSIFL ISFVALIACV SHNPLYMMVL 540
RVVNQDEKSF AIGVQFLLMR LLAWLPSPSL YGLLIDSSCI RWNYLCSGRR GACAYYDNDA 600
LRNRYLGLQV IYKVLGTLLL FFISWRVKKN REYSLQENAS GLI 643 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IC:MGI. GO:0015132; F:prostaglandin transmembrane transporter activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |