| Tag | Content |
|---|
| CPLM ID | CPLM-022377 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier organic anion transporter family member 1C1 |
Protein Synonyms/Alias | Organic anion transporter F; OATP-F; Organic anion transporter polypeptide-related protein 5; OAT-RP-5; OATPRP5; Organic anion-transporting polypeptide 14; OATP-14; Solute carrier family 21 member 14; Thyroxine transporter |
Gene Name | SLCO1C1 |
Gene Synonyms/Alias | OATP14; OATP1C1; OATPF; SLC21A14 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 673 | SCHFTACKTYISGTN | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity). |
Sequence Annotation | DOMAIN 470 525 Kazal-like.
CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
CARBOHYD 510 510 N-linked (GlcNAc...) (Potential).
CARBOHYD 520 520 N-linked (GlcNAc...) (Potential).
CARBOHYD 533 533 N-linked (GlcNAc...) (Potential).
DISULFID 476 502 By similarity.
DISULFID 480 491 By similarity.
DISULFID 482 506 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 712 AA |
Protein Sequence | MDTSSKENIQ LFCKTSVQPV GRPSFKTEYP SSEEKQPCCG ELKVFLCALS FVYFAKALAE 60
GYLKSTITQI ERRFDIPSSL VGVIDGSFEI GNLLVITFVS YFGAKLHRPK IIGAGCVIMG 120
VGTLLIAMPQ FFMEQYKYER YSPSSNSTLS ISPCLLESSS QLPVSVMEKS KSKISNECEV 180
DTSSSMWIYV FLGNLLRGIG ETPIQPLGIA YLDDFASEDN AAFYIGCVQT VAIIGPIFGF 240
LLGSLCAKLY VDIGFVNLDH ITITPKDPQW VGAWWLGYLI AGIISLLAAV PFWYLPKSLP 300
RSQSREDSNS SSEKSKFIID DHTDYQTPQG ENAKIMEMAR DFLPSLKNLF GNPVYFLYLC 360
TSTVQFNSLF GMVTYKPKYI EQQYGQSSSR ANFVIGLINI PAVALGIFSG GIVMKKFRIS 420
VCGAAKLYLG SSVFGYLLFL SLFALGCENS DVAGLTVSYQ GTKPVSYHER ALFSDCNSRC 480
KCSETKWEPM CGENGITYVS ACLAGCQTSN RSGKNIIFYN CTCVGIAASK SGNSSGIVGR 540
CQKDNGCPQM FLYFLVISVI TSYTLSLGGI PGYILLLRCI KPQLKSFALG IYTLAIRVLA 600
GIPAPVYFGV LIDTSCLKWG FKRCGSRGSC RLYDSNVFRY QIKSIPASHC YSIPDLHNAT 660
DTNKFSCHFT ACKTYISGTN CDTGHSVNSP KHCSTFHFKE KLCFKTQKFY NQERKNNGVY 720
KIPKGKLHYK 730 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005215; F:transporter activity; IEA:InterPro. GO:0043252; P:sodium-independent organic anion transport; TAS:Reactome. GO:0055085; P:transmembrane transport; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |