CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001252
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gap junction beta-3 protein 
Protein Synonyms/Alias
 Connexin-31; Cx31 
Gene Name
 GJB3 
Gene Synonyms/Alias
 CX31 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
259DPDPGNNKLQASAPNubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
Sequence Annotation
  
Keyword
 Cell junction; Cell membrane; Complete proteome; Deafness; Disease mutation; Gap junction; Membrane; Non-syndromic deafness; Palmoplantar keratoderma; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 270 AA 
Protein Sequence
MDWKTLQALL SGVNKYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD FDCNTKQPGC 60
TNVCYDNYFP ISNIRLWALQ LIFVTCPSLL VILHVAYREE RERRHRQKHG DQCAKLYDNA 120
GKKHGGLWWT YLFSLIFKLI IEFLFLYLLH TLWHGFNMPR LVQCANVAPC PNIVDCYIAR 180
PTEKKIFTYF MVGASAVCIV LTICELCYLI CHRVLRGLHK DKPRGGCSPS SSASRASTCR 240
CHHKLVEAGE VDPDPGNNKL QASAPNLTPI 270 
Gene Ontology
 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005921; C:gap junction; NAS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005243; F:gap junction channel activity; NAS:UniProtKB.
 GO:0007154; P:cell communication; NAS:UniProtKB.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0001890; P:placenta development; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara. 
Interpro
 IPR000500; Connexin.
 IPR002269; Connexin31.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 
Pfam
 PF00029; Connexin
 PF10582; Connexin_CCC 
SMART
 SM00037; CNX
 SM01089; Connexin_CCC 
PROSITE
 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 
PRINTS
 PR00206; CONNEXIN.
 PR01140; CONNEXINB3.