| Tag | Content |
|---|
| CPLM ID | CPLM-009224 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | HERV-F(c)2_7q36.2 provirus ancestral Env polyprotein |
Protein Synonyms/Alias | Envelope polyprotein; Fc2deltaenv; Surface protein; SU; Truncated transmembrane protein; TM |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 117 | SSLGPARKNPALCFL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties. |
Sequence Annotation | REGION 1 411 Surface protein (By similarity).
REGION 412 527 Transmembrane protein (By similarity).
REGION 412 432 Fusion peptide (Potential).
MOTIF 280 283 CXXC (By similarity).
MOTIF 477 493 CKS-17 (By similarity).
MOTIF 494 502 CX6CC (By similarity).
DISULFID 494 501 By similarity. |
Keyword | Complete proteome; Disulfide bond; ERV; Reference proteome; Ribosomal frameshifting; Transposable element; Viral envelope protein; Virion. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 527 AA |
Protein Sequence | MNSPCDRLQQ FIQVLLEESW SFPSFANTLH WPENLLSYID ELVWQGSLQN FHQHEVRFDK 60
PPLRLPLTGF SSLTENWSSR QAVSSRLVAT AASPPAGCQA PIAFLGLKFS SLGPARKNPA 120
LCFLYDQSNS KCNTSWVKEN VGCPWHWCNI HEALIRTEKG SDPMFYVNTS TGGRDGFNGF 180
NLQISDPWDP RWASGVDGGL YEHKTFMYPV AKIRIARTLK TTVTGLSDLA SSIQSAEKEL 240
TSQLQPAADQ AKSSRFSWLT LISEGAQLLQ STGVQNLSHC FLCAALRRPP LVAVPLPTPF 300
NYTINSSTPI PPVPKGQVPL FSDPIRHKFP FCYSTPNASW CNQTRMLTST PAPPRGYFWC 360
NSTLTKVLNS TGNHTLCLPI SLIPGLTLYS QDELSHLLAW TEPRPQNKSK WAIFLPLVLG 420
ISLASSLVAS GLGKGALTHS IQTSQDLSTH LQLAIEASAE SLDSLQRQIT TVAQVAAQNR 480
QALDLLMAEK GRTCLFLQEE CCYYLNESGV VENSLQTLKK KKSSKRS 527 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |