| Tag | Content |
|---|
| CPLM ID | CPLM-005854 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Creatine kinase U-type, mitochondrial |
Protein Synonyms/Alias | Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK |
Gene Name | Ckmt1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 59 | AEYPDLRKHNNCMAS | ubiquitination | [1] | | 200 | VDALSGLKGDLAGRY | ubiquitination | [1] | | 344 | SKDNRFPKILENLRL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
Sequence Annotation | DOMAIN 46 132 Phosphagen kinase N-terminal.
DOMAIN 159 401 Phosphagen kinase C-terminal.
NP_BIND 162 166 ATP (By similarity).
NP_BIND 354 359 ATP (By similarity).
REGION 40 64 Cardiolipin-binding (By similarity).
BINDING 225 225 ATP (By similarity).
BINDING 270 270 ATP (By similarity).
BINDING 326 326 ATP (By similarity).
BINDING 369 369 ATP (By similarity).
MOD_RES 154 154 Phosphotyrosine.
MOD_RES 313 313 Nitrated tyrosine. |
Keyword | ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Membrane; Mitochondrion; Mitochondrion inner membrane; Nitration; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 418 AA |
Protein Sequence | MAGPFSRLLS ARPGLRLLAL AGAGSLTAGI LLRPESVGAA AAERRRLYPP SAEYPDLRKH 60
NNCMASHLTP AVYARLCDKT TPTGWTLDQC IQTGVDNPGH PFIKTVGMVA GDEETYEVFA 120
ELFDPVIQER HNGYDPRTMK HTTDLDASKI RSGYFDERYV LSSRVRTGRS IRGLSLPPAC 180
TRAERREVER VVVDALSGLK GDLAGRYYRL SEMTEAEQQQ LIDDHFLFDK PVSPLLTAAG 240
MARDWPDARG IWHNNEKSFL IWVNEEDHTR VISMEKGGNM KRVFERFCRG LKEVEKLIQE 300
RGWEFMWNER LGYILTCPSN LGTGLRAGVH IKLPLLSKDN RFPKILENLR LQKRGTGGVD 360
TAATGSVFDI SNLDRLGKSE VELVQLVIDG VNYLIDCERR LERGQDIRIP PPLVHSKH 418 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |