CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017097
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent RNA helicase SUPV3L1, mitochondrial 
Protein Synonyms/Alias
 Suppressor of var1 3-like protein 1; SUV3-like protein 1 
Gene Name
 SUPV3L1 
Gene Synonyms/Alias
 SUV3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
99EVKKVLDKFYKRKEIacetylation[1]
220KTYHAIQKYFSAKSGacetylation[1, 2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 
Functional Description
 Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP- dependent multisubstrate helicase, able to unwind double stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. 
Sequence Annotation
 DOMAIN 194 334 Helicase ATP-binding.
 DOMAIN 353 518 Helicase C-terminal.
 NP_BIND 207 214 ATP.
 REGION 650 786 Interaction with LAMTOR5, important for
 MOD_RES 99 99 N6-acetyllysine.
 MOD_RES 220 220 N6-acetyllysine.
 MOD_RES 725 725 Phosphoserine.  
Keyword
 3D-structure; Acetylation; ATP-binding; Complete proteome; Helicase; Hydrolase; Mitochondrion; Mitochondrion nucleoid; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 786 AA 
Protein Sequence
MSFSRALLWA RLPAGRQAGH RAAICSALRP HFGPFPGVLG QVSVLATASS SASGGSKIPN 60
TSLFVPLTVK PQGPSADGDV GAELTRPLDK NEVKKVLDKF YKRKEIQKLG ADYGLDARLF 120
HQAFISFRNY IMQSHSLDVD IHIVLNDICF GAAHADDLFP FFLRHAKQIF PVLDCKDDLR 180
KISDLRIPPN WYPDARAMQR KIIFHSGPTN SGKTYHAIQK YFSAKSGVYC GPLKLLAHEI 240
FEKSNAAGVP CDLVTGEERV TVQPNGKQAS HVSCTVEMCS VTTPYEVAVI DEIQMIRDPA 300
RGWAWTRALL GLCAEEVHLC GEPAAIDLVM ELMYTTGEEV EVRDYKRLTP ISVLDHALES 360
LDNLRPGDCI VCFSKNDIYS VSRQIEIRGL ESAVIYGSLP PGTKLAQAKK FNDPNDPCKI 420
LVATDAIGMG LNLSIRRIIF YSLIKPSINE KGERELEPIT TSQALQIAGR AGRFSSRFKE 480
GEVTTMNHED LSLLKEILKR PVDPIRAAGL HPTAEQIEMF AYHLPDATLS NLIDIFVDFS 540
QVDGQYFVCN MDDFKFSAEL IQHIPLSLRV RYVFCTAPIN KKQPFVCSSL LQFARQYSRN 600
EPLTFAWLRR YIKWPLLPPK NIKDLMDLEA VHDVLDLYLW LSYRFMDMFP DASLIRDLQK 660
ELDGIIQDGV HNITKLIKMS ETHKLLNLEG FPSGSQSRLS GTLKSQARRT RGTKALGSKA 720
TEPPSPDAGE LSLASRLVQQ GLLTPDMLKQ LEKEWMTQQT EHNKEKTESG THPKGTRRKK 780
KEPDSD 786 
Gene Ontology
 GO:0045025; C:mitochondrial degradosome; IDA:UniProtKB.
 GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0034458; F:3'-5' RNA helicase activity; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004004; F:ATP-dependent RNA helicase activity; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IMP:UniProtKB.
 GO:0003678; F:DNA helicase activity; IMP:UniProtKB.
 GO:0003725; F:double-stranded RNA binding; IDA:UniProtKB.
 GO:0070827; P:chromatin maintenance; IMP:UniProtKB.
 GO:0006310; P:DNA recombination; IMP:UniProtKB.
 GO:0000958; P:mitochondrial mRNA catabolic process; IMP:UniProtKB.
 GO:0035946; P:mitochondrial mRNA surveillance; IMP:UniProtKB.
 GO:0035945; P:mitochondrial ncRNA surveillance; IMP:UniProtKB.
 GO:0000965; P:mitochondrial RNA 3'-end processing; IMP:UniProtKB.
 GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0030307; P:positive regulation of cell growth; IMP:UniProtKB.
 GO:0000962; P:positive regulation of mitochondrial RNA catabolic process; IDA:UniProtKB. 
Interpro
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR022192; SUV3_C. 
Pfam
 PF00271; Helicase_C
 PF12513; SUV3_C 
SMART
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS