| Tag | Content |
|---|
| CPLM ID | CPLM-008060 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribonucleoside-diphosphate reductase subunit M2 |
Protein Synonyms/Alias | Ribonucleotide reductase small subunit |
Gene Name | RnrS |
Gene Synonyms/Alias | CG8975 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 56 | STVNGIGKSANSLME | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. |
Sequence Annotation | ACT_SITE 180 180 By similarity.
METAL 142 142 Iron 1 (By similarity).
METAL 173 173 Iron 1 (By similarity).
METAL 173 173 Iron 2 (By similarity).
METAL 176 176 Iron 1 (By similarity).
METAL 236 236 Iron 2 (By similarity).
METAL 270 270 Iron 2 (By similarity).
METAL 273 273 Iron 2 (By similarity).
MOD_RES 18 18 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; DNA replication; Iron; Metal-binding; Oxidoreductase; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 393 AA |
Protein Sequence | MASKENIADN MEKFSLKSPS KKILTDSTNN VRKMSIGHEA NGQLAKESST VNGIGKSANS 60
LMEKSVTPFD PSLEPLLREN PRRFVIFPIQ YHDIWQMYKK AEASFWTVEE VDLSKDLTDW 120
HRLKDDERHF ISHVLAFFAA SDGIVNENLV ERFSQEVQIT EARCFYGFQI AMENVHSEMY 180
SVLIDTYIRD PHQREYLFNA IETMPAVKRK ADWALSWISS KSANFGERII AFAAVEGIFF 240
SGSFASIFWL KKRGLMPGLT FSNELISRDE GLHCDFAVLM FQHLVQRPKR ERIIEIIRDA 300
VAIEQEFLTD ALPVNLIGMN CDLMSQYIEF VADRLLVELG VGKIYNTKNP FNFMEMISLD 360
GKTNFFEKKV GEYQRMGVVS NPLDNVFTLD ADF 393 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:EC. GO:0046914; F:transition metal ion binding; IEA:InterPro. GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:FlyBase. GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:InterPro. GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway. GO:0022008; P:neurogenesis; IMP:FlyBase. |
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Pfam | |
SMART | |
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PRINTS | |