CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039633
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ADP-ribosylation factor-like protein 6-interacting protein 1 
Protein Synonyms/Alias
  
Gene Name
 ARL6IP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67PRIFGSNKWTTEQQQubiquitination[1, 2, 3, 4, 5, 6, 7]
85EICSNLVKTRRRAVGubiquitination[1, 2, 3, 5, 6, 7]
95RRAVGWWKRLFTLKEubiquitination[1, 6]
159LKYIGMAKREINKLLubiquitination[6]
164MAKREINKLLKQKEKubiquitination[6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 174 AA 
Protein Sequence
MLMADKVLRW ERAWFPPAIM GVVSLVFLII YYLDPSVLSG VSCFVMFLCL ADYLVPILAP 60
RIFGSNKWTT EQQQRFHEIC SNLVKTRRRA VGWWKRLFTL KEEKPKMYFM TMIVSLAAVA 120
WVGQQVHNLL LTYLIVTSLL LLPGLNQHGI ILKYIGMAKR EINKLLKQKE KKNE 174 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0016021; C:integral to membrane; IEA:Compara.
 GO:0005784; C:Sec61 translocon complex; IEA:Compara.
 GO:0006613; P:cotranslational protein targeting to membrane; IEA:Compara. 
Interpro
 IPR003388; Reticulon. 
Pfam
 PF02453; Reticulon 
SMART
  
PROSITE
  
PRINTS