CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014948
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type I cytoskeletal 10 
Protein Synonyms/Alias
 Cytokeratin-10; CK-10; Keratin-10; K10; Type I keratin Ka10 
Gene Name
 Krt10 
Gene Synonyms/Alias
 Ka10 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
162RLASYMNKVRDLEESacetylation[1]
176SNYELEGKIKEWYEKacetylation[1]
178YELEGKIKEWYEKHGacetylation[1]
183KIKEWYEKHGNSSQRacetylation[1]
197REPRDYSKYYKTIEDacetylation[1]
200RDYSKYYKTIEDLKGacetylation[1]
236AADDFRLKYENEVALacetylation[1]
330QYEQLAEKNRKDAEAacetylation[1]
333QLAEKNRKDAEAWFNacetylation[1]
342AEAWFNEKSKELTTEacetylation[1]
361IEQMSSHKSEITELRacetylation[1]
438YQQLLDIKTRLENEIacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 REGION 1 144 Head.
 REGION 145 455 Rod.
 REGION 145 180 Coil 1A.
 REGION 181 201 Linker 1.
 REGION 202 293 Coil 1B.
 REGION 294 316 Linker 12.
 REGION 317 455 Coil 2.
 REGION 456 526 Tail.
 MOD_RES 17 17 Phosphoserine (By similarity).
 MOD_RES 38 38 Phosphoserine (By similarity).
 MOD_RES 52 52 Phosphoserine (By similarity).
 MOD_RES 352 352 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Intermediate filament; Keratin; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MSVRFSSNSR QYSSARSGGG GGGGGGGSSI RVSSTKSSLG GGYSSGGFSG GSFSRGSSSG 60
GCFGGSSGGY GGFGGGSFGG GYGGGSFGGG YGGGSFGGGY GGGSFGGGYG GGSFGGGSFG 120
GGSFGGGSFG GGLGGDGGGL LSGNEKVTMQ NLNDRLASYM NKVRDLEESN YELEGKIKEW 180
YEKHGNSSQR EPRDYSKYYK TIEDLKGQIV NLTTDNANVL LQIDNARLAA DDFRLKYENE 240
VALRQSVEAD INGLRRVLDE LTLSKADLEM QIESLTEELA YLKKNHEEEM KDLQNVSTGD 300
VNVEMNAAPG VDLTQLLNNM RNQYEQLAEK NRKDAEAWFN EKSKELTTEI DSNIEQMSSH 360
KSEITELRRT VQGLEIELQS QLALKQSLEA SLAETEGRYC VQLSQIQSQI SALEEQLQQI 420
RAETECQNAE YQQLLDIKTR LENEIQTYRS LLEGEGGYVG NLQITLNCFP SEFHLAKLTQ 480
TQGKTRGWKG SNTNKTRVIK TIIEEVTPEG RVLSSMIESE TKKHFY 526 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0045095; C:keratin filament; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0071277; P:cellular response to calcium ion; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR002957; Keratin_I. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01248; TYPE1KERATIN.