CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004506
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarylacetoacetase 
Protein Synonyms/Alias
 FAA; Beta-diketonase; Fumarylacetoacetate hydrolase 
Gene Name
 FAH 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
144VGIMFRDKENALMPNubiquitination[1]
241WSARDIQKWEYVPLGacetylation[2, 3]
241WSARDIQKWEYVPLGubiquitination[4, 5]
411GFGQCAGKVLPALLPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 ACT_SITE 133 133 Proton acceptor (Probable).
 METAL 126 126 Calcium (By similarity).
 METAL 199 199 Calcium (By similarity).
 METAL 201 201 Calcium (By similarity).
 METAL 233 233 Calcium (By similarity).
 METAL 233 233 Magnesium (By similarity).
 METAL 253 253 Magnesium (By similarity).
 METAL 257 257 Magnesium (By similarity).
 BINDING 128 128 Substrate (By similarity).
 BINDING 142 142 Substrate (By similarity).
 BINDING 240 240 Substrate (By similarity).
 BINDING 244 244 Substrate (By similarity).
 BINDING 350 350 Substrate (By similarity).
 MOD_RES 2 2 N-acetylserine.  
Keyword
 Acetylation; Calcium; Complete proteome; Direct protein sequencing; Disease mutation; Hydrolase; Magnesium; Metal-binding; Phenylalanine catabolism; Reference proteome; Tyrosine catabolism. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 419 AA 
Protein Sequence
MSFIPVAEDS DFPIHNLPYG VFSTRGDPRP RIGVAIGDQI LDLSIIKHLF TGPVLSKHQD 60
VFNQPTLNSF MGLGQAAWKE ARVFLQNLLS VSQARLRDDT ELRKCAFISQ ASATMHLPAT 120
IGDYTDFYSS RQHATNVGIM FRDKENALMP NWLHLPVGYH GRASSVVVSG TPIRRPMGQM 180
KPDDSKPPVY GACKLLDMEL EMAFFVGPGN RLGEPIPISK AHEHIFGMVL MNDWSARDIQ 240
KWEYVPLGPF LGKSFGTTVS PWVVPMDALM PFAVPNPKQD PRPLPYLCHD EPYTFDINLS 300
VNLKGEGMSQ AATICKSNFK YMYWTMLQQL THHSVNGCNL RPGDLLASGT ISGPEPENFG 360
SMLELSWKGT KPIDLGNGQT RKFLLDGDEV IITGYCQGDG YRIGFGQCAG KVLPALLPS 419 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0004334; F:fumarylacetoacetase activity; EXP:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006527; P:arginine catabolic process; IEA:Compara.
 GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.
 GO:0006559; P:L-phenylalanine catabolic process; TAS:Reactome.
 GO:0006572; P:tyrosine catabolic process; TAS:ProtInc. 
Interpro
 IPR005959; Fumarylacetoacetase.
 IPR002529; Fumarylacetoacetase_C.
 IPR011234; Fumarylacetoacetase_C-rel.
 IPR015377; Fumarylacetoacetase_N. 
Pfam
 PF09298; DUF1969
 PF01557; FAA_hydrolase 
SMART
  
PROSITE
  
PRINTS