UniProt Accession

 SRRM2_MOUSE; Q8BTI8; E9QNB0; Q3TBY5; Q569P9; Q80U37; Q8K383 

Genbank Protein ID

 AK090123; AK171001; AC122821; BC027781; BC092355; AK122248 

Genbank Nucleotide ID

 BAC41104.1; BAE42172.1; AAH27781.1; AAH92355.1; BAC65530.1 

Protein Name

 Serine/arginine repetitive matrix protein 2 

Protein Synonyms/Alias

  

Gene Name

 Srrm2 

Gene Synonyms/Alias

 Kiaa0324 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
101	FRLMLLEKDVNPGAK	acetylation	[1]
169	QIAPEPPKPYSLVRE	acetylation	[1, 2]
1091	SEISTDPKLKSGMSP	acetylation	[1]
1116	IYPLVDSKSFLVQSR	ubiquitination	[3]
1130	RLEPSELKERLGLIQ	ubiquitination	[3]
1187	PPGKRDQKSLLPNSS	acetylation	[4]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate. Binds to RNA (By similarity). 

Sequence Annotation

 REGION 197 259 Sufficient for RNA-binding (By
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 24 24 Phosphoserine (By similarity).
 MOD_RES 145 145 Phosphotyrosine (By similarity).
 MOD_RES 169 169 N6-acetyllysine (By similarity).
 MOD_RES 220 220 Phosphoserine (By similarity).
 MOD_RES 222 222 Phosphoserine (By similarity).
 MOD_RES 295 295 Phosphoserine (By similarity).
 MOD_RES 300 300 Phosphoserine (By similarity).
 MOD_RES 322 322 Phosphoserine (By similarity).
 MOD_RES 323 323 Phosphoserine (By similarity).
 MOD_RES 333 333 Phosphoserine (By similarity).
 MOD_RES 349 349 Phosphoserine.
 MOD_RES 351 351 Phosphoserine.
 MOD_RES 355 355 Phosphoserine (By similarity).
 MOD_RES 356 356 Phosphoserine (By similarity).
 MOD_RES 357 357 Phosphothreonine (By similarity).
 MOD_RES 365 365 Phosphothreonine (By similarity).
 MOD_RES 375 375 Phosphoserine (By similarity).
 MOD_RES 385 385 Phosphoserine (By similarity).
 MOD_RES 396 396 Phosphoserine (By similarity).
 MOD_RES 402 402 Phosphoserine.
 MOD_RES 406 406 Phosphoserine.
 MOD_RES 422 422 Phosphoserine (By similarity).
 MOD_RES 433 433 Phosphoserine.
 MOD_RES 434 434 Phosphoserine.
 MOD_RES 435 435 Phosphoserine.
 MOD_RES 438 438 Phosphoserine.
 MOD_RES 452 452 Phosphoserine (By similarity).
 MOD_RES 470 470 Phosphoserine.
 MOD_RES 472 472 Phosphoserine.
 MOD_RES 482 482 Phosphoserine (By similarity).
 MOD_RES 484 484 Phosphoserine (By similarity).
 MOD_RES 531 531 Phosphoserine.
 MOD_RES 533 533 Phosphoserine.
 MOD_RES 622 622 Phosphoserine.
 MOD_RES 624 624 Phosphothreonine.
 MOD_RES 626 626 Phosphoserine.
 MOD_RES 773 773 Phosphoserine.
 MOD_RES 775 775 Phosphoserine.
 MOD_RES 778 778 Phosphoserine.
 MOD_RES 821 821 Phosphoserine (By similarity).
 MOD_RES 823 823 Phosphothreonine.
 MOD_RES 841 841 Phosphothreonine (By similarity).
 MOD_RES 846 846 Phosphoserine (By similarity).
 MOD_RES 850 850 Phosphoserine (By similarity).
 MOD_RES 851 851 Phosphoserine (By similarity).
 MOD_RES 882 882 Phosphoserine (By similarity).
 MOD_RES 898 898 Phosphoserine.
 MOD_RES 924 924 Phosphoserine.
 MOD_RES 926 926 Phosphoserine.
 MOD_RES 928 928 Phosphoserine.
 MOD_RES 940 940 Phosphoserine (By similarity).
 MOD_RES 942 942 Phosphoserine (By similarity).
 MOD_RES 944 944 Phosphoserine.
 MOD_RES 945 945 Phosphoserine.
 MOD_RES 946 946 Phosphoserine.
 MOD_RES 955 955 Phosphothreonine (By similarity).
 MOD_RES 962 962 Phosphoserine (By similarity).
 MOD_RES 964 964 Phosphoserine (By similarity).
 MOD_RES 973 973 Phosphothreonine.
 MOD_RES 984 984 Phosphoserine (By similarity).
 MOD_RES 997 997 Phosphoserine (By similarity).
 MOD_RES 1000 1000 Phosphoserine (By similarity).
 MOD_RES 1037 1037 Phosphoserine (By similarity).
 MOD_RES 1038 1038 Phosphoserine (By similarity).
 MOD_RES 1048 1048 Phosphoserine (By similarity).
 MOD_RES 1064 1064 Phosphoserine (By similarity).
 MOD_RES 1066 1066 Phosphoserine (By similarity).
 MOD_RES 1067 1067 Phosphoserine (By similarity).
 MOD_RES 1068 1068 Phosphoserine.
 MOD_RES 1071 1071 Phosphothreonine (By similarity).
 MOD_RES 1077 1077 Phosphoserine (By similarity).
 MOD_RES 1087 1087 Phosphoserine (By similarity).
 MOD_RES 1094 1094 Phosphoserine (By similarity).
 MOD_RES 1097 1097 Phosphoserine (By similarity).
 MOD_RES 1117 1117 Phosphoserine (By similarity).
 MOD_RES 1151 1151 Phosphoserine.
 MOD_RES 1175 1175 Phosphoserine (By similarity).
 MOD_RES 1209 1209 Phosphoserine.
 MOD_RES 1216 1216 Phosphoserine.
 MOD_RES 1276 1276 Phosphoserine (By similarity).
 MOD_RES 1278 1278 Phosphoserine.
 MOD_RES 1284 1284 Phosphoserine (By similarity).
 MOD_RES 1287 1287 Phosphoserine (By similarity).
 MOD_RES 1294 1294 Phosphoserine (By similarity).
 MOD_RES 1305 1305 Phosphoserine.
 MOD_RES 1325 1325 Phosphoserine (By similarity).
 MOD_RES 1334 1334 Phosphoserine.
 MOD_RES 1338 1338 Phosphoserine.
 MOD_RES 1339 1339 Phosphoserine.
 MOD_RES 1340 1340 Phosphoserine.
 MOD_RES 1343 1343 Phosphoserine.
 MOD_RES 1359 1359 Phosphoserine.
 MOD_RES 1360 1360 Phosphoserine.
 MOD_RES 1370 1370 Phosphothreonine (By similarity).
 MOD_RES 1372 1372 Phosphoserine (By similarity).
 MOD_RES 1376 1376 Phosphoserine.
 MOD_RES 1377 1377 Phosphoserine.
 MOD_RES 1378 1378 Phosphoserine.
 MOD_RES 1380 1380 Phosphoserine.
 MOD_RES 1390 1390 Phosphothreonine (By similarity).
 MOD_RES 1400 1400 Phosphoserine (By similarity).
 MOD_RES 1407 1407 Phosphoserine (By similarity).
 MOD_RES 1409 1409 Phosphothreonine (By similarity).
 MOD_RES 1414 1414 Phosphoserine.
 MOD_RES 1416 1416 Phosphoserine (By similarity).
 MOD_RES 1418 1418 Phosphoserine (By similarity).
 MOD_RES 1419 1419 Phosphoserine (By similarity).
 MOD_RES 1428 1428 Phosphothreonine (By similarity).
 MOD_RES 1434 1434 Phosphoserine.
 MOD_RES 1438 1438 Phosphoserine.
 MOD_RES 1439 1439 Phosphoserine.
 MOD_RES 1448 1448 Phosphothreonine.
 MOD_RES 1453 1453 Phosphoserine.
 MOD_RES 1455 1455 Phosphoserine (By similarity).
 MOD_RES 1457 1457 Phosphoserine (By similarity).
 MOD_RES 1458 1458 Phosphoserine.
 MOD_RES 1467 1467 Phosphothreonine (By similarity).
 MOD_RES 1473 1473 Phosphoserine (By similarity).
 MOD_RES 1475 1475 Phosphoserine (By similarity).
 MOD_RES 1477 1477 Phosphoserine (By similarity).
 MOD_RES 1478 1478 Phosphoserine (By similarity).
 MOD_RES 1487 1487 Phosphothreonine (By similarity).
 MOD_RES 1493 1493 Phosphoserine (By similarity).
 MOD_RES 1495 1495 Phosphoserine (By similarity).
 MOD_RES 1497 1497 Phosphoserine (By similarity).
 MOD_RES 1498 1498 Phosphoserine (By similarity).
 MOD_RES 1508 1508 Phosphoserine.
 MOD_RES 1513 1513 Phosphoserine.
 MOD_RES 1515 1515 Phosphoserine.
 MOD_RES 1533 1533 Phosphoserine.
 MOD_RES 1535 1535 Phosphoserine.
 MOD_RES 1537 1537 Phosphoserine.
 MOD_RES 1538 1538 Phosphoserine.
 MOD_RES 1545 1545 Phosphoserine.
 MOD_RES 1548 1548 Phosphoserine.
 MOD_RES 1552 1552 Phosphoserine.
 MOD_RES 1554 1554 Phosphoserine (By similarity).
 MOD_RES 1556 1556 Phosphoserine (By similarity).
 MOD_RES 1557 1557 Phosphoserine (By similarity).
 MOD_RES 1572 1572 Phosphoserine.
 MOD_RES 1574 1574 Phosphothreonine.
 MOD_RES 1576 1576 Phosphoserine.
 MOD_RES 1577 1577 Phosphoserine.
 MOD_RES 1604 1604 Phosphoserine (By similarity).
 MOD_RES 1614 1614 Phosphoserine (By similarity).
 MOD_RES 1631 1631 Phosphoserine.
 MOD_RES 1647 1647 Phosphoserine (By similarity).
 MOD_RES 1649 1649 Phosphoserine (By similarity).
 MOD_RES 1650 1650 Phosphoserine (By similarity).
 MOD_RES 1654 1654 Phosphothreonine.
 MOD_RES 1683 1683 Phosphoserine (By similarity).
 MOD_RES 1685 1685 Phosphoserine (By similarity).
 MOD_RES 1687 1687 Phosphoserine (By similarity).
 MOD_RES 1688 1688 Phosphoserine (By similarity).
 MOD_RES 1718 1718 Phosphoserine.
 MOD_RES 1720 1720 Phosphoserine.
 MOD_RES 1747 1747 Phosphoserine.
 MOD_RES 1749 1749 Phosphoserine.
 MOD_RES 1774 1774 Phosphoserine (By similarity).
 MOD_RES 1778 1778 Phosphoserine (By similarity).
 MOD_RES 1798 1798 Phosphoserine.
 MOD_RES 1800 1800 Phosphothreonine.
 MOD_RES 1810 1810 Phosphoserine (By similarity).
 MOD_RES 1813 1813 Phosphoserine.
 MOD_RES 1822 1822 Phosphoserine.
 MOD_RES 1832 1832 Phosphoserine (By similarity).
 MOD_RES 1834 1834 Phosphoserine (By similarity).
 MOD_RES 1836 1836 Phosphothreonine (By similarity).
 MOD_RES 1840 1840 Phosphoserine (By similarity).
 MOD_RES 1844 1844 Phosphoserine.
 MOD_RES 1846 1846 Phosphoserine.
 MOD_RES 1848 1848 Phosphothreonine (By similarity).
 MOD_RES 1849 1849 Phosphoserine.
 MOD_RES 1864 1864 Phosphoserine.
 MOD_RES 1866 1866 Phosphoserine.
 MOD_RES 1869 1869 Phosphoserine.
 MOD_RES 1872 1872 Phosphoserine (By similarity).
 MOD_RES 1876 1876 Phosphoserine (By similarity).
 MOD_RES 1878 1878 Phosphoserine (By similarity).
 MOD_RES 1880 1880 Phosphothreonine (By similarity).
 MOD_RES 1884 1884 Phosphothreonine (By similarity).
 MOD_RES 1898 1898 Phosphoserine (By similarity).
 MOD_RES 1900 1900 Phosphoserine (By similarity).
 MOD_RES 1902 1902 Phosphothreonine (By similarity).
 MOD_RES 1906 1906 Phosphothreonine (By similarity).
 MOD_RES 1910 1910 Phosphoserine.
 MOD_RES 1912 1912 Phosphoserine.
 MOD_RES 1914 1914 Phosphothreonine.
 MOD_RES 1918 1918 Phosphothreonine (By similarity).
 MOD_RES 1922 1922 Phosphoserine (By similarity).
 MOD_RES 1924 1924 Phosphoserine (By similarity).
 MOD_RES 1927 1927 Phosphoserine (By similarity).
 MOD_RES 1930 1930 Phosphothreonine (By similarity).
 MOD_RES 1936 1936 Phosphoserine (By similarity).
 MOD_RES 1939 1939 Phosphoserine (By similarity).
 MOD_RES 1948 1948 Phosphoserine (By similarity).
 MOD_RES 1951 1951 Phosphoserine (By similarity).
 MOD_RES 1958 1958 Phosphoserine.
 MOD_RES 1960 1960 Phosphoserine.
 MOD_RES 1962 1962 Phosphothreonine.
 MOD_RES 1963 1963 Phosphoserine.
 MOD_RES 1972 1972 Phosphoserine (By similarity).
 MOD_RES 1974 1974 Phosphothreonine (By similarity).
 MOD_RES 1982 1982 Phosphoserine.
 MOD_RES 1984 1984 Phosphoserine.
 MOD_RES 1986 1986 Phosphothreonine.
 MOD_RES 1994 1994 Phosphoserine.
 MOD_RES 1996 1996 Phosphoserine.
 MOD_RES 1998 1998 Phosphoserine.
 MOD_RES 2019 2019 Phosphoserine.
 MOD_RES 2021 2021 Phosphothreonine.
 MOD_RES 2023 2023 Phosphoserine.
 MOD_RES 2042 2042 Phosphoserine (By similarity).
 MOD_RES 2044 2044 Phosphothreonine (By similarity).
 MOD_RES 2052 2052 Phosphoserine.
 MOD_RES 2054 2054 Phosphoserine.
 MOD_RES 2056 2056 Phosphothreonine.
 MOD_RES 2070 2070 Phosphoserine (By similarity).
 MOD_RES 2073 2073 Phosphoserine.
 MOD_RES 2075 2075 Phosphoserine (By similarity).
 MOD_RES 2084 2084 Phosphoserine (By similarity).
 MOD_RES 2096 2096 Phosphothreonine (By similarity).
 MOD_RES 2224 2224 Phosphoserine.
 MOD_RES 2241 2241 Phosphothreonine (By similarity).
 MOD_RES 2254 2254 Phosphothreonine (By similarity).
 MOD_RES 2268 2268 Phosphothreonine (By similarity).
 MOD_RES 2281 2281 Phosphothreonine (By similarity).
 MOD_RES 2296 2296 Phosphoserine (By similarity).
 MOD_RES 2334 2334 Phosphothreonine (By similarity).
 MOD_RES 2335 2335 Phosphoserine.
 MOD_RES 2347 2347 Phosphoserine (By similarity).
 MOD_RES 2351 2351 Phosphoserine.
 MOD_RES 2360 2360 Phosphoserine.
 MOD_RES 2362 2362 Phosphothreonine.
 MOD_RES 2365 2365 Phosphoserine (By similarity).
 MOD_RES 2368 2368 Phosphoserine (By similarity).
 MOD_RES 2381 2381 Phosphoserine.
 MOD_RES 2384 2384 Phosphoserine (By similarity).
 MOD_RES 2404 2404 Phosphoserine.
 MOD_RES 2408 2408 Phosphoserine (By similarity).
 MOD_RES 2535 2535 Phosphoserine (By similarity).
 MOD_RES 2537 2537 Phosphothreonine.
 MOD_RES 2618 2618 Phosphoserine.
 MOD_RES 2629 2629 Phosphoserine (By similarity).
 MOD_RES 2631 2631 Phosphoserine (By similarity).
 MOD_RES 2638 2638 Phosphoserine.
 MOD_RES 2642 2642 Phosphoserine.
 MOD_RES 2644 2644 Phosphoserine.
 MOD_RES 2646 2646 Phosphoserine.
 MOD_RES 2647 2647 Phosphotyrosine.
 MOD_RES 2648 2648 Phosphoserine.
 MOD_RES 2656 2656 Phosphoserine.
 MOD_RES 2660 2660 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 2703 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IEA:Compara.
 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR013170; mRNA_splic_Cwf21.
 IPR024945; Spt5_C_dom. 

Pfam

 PF08312; cwf21 

SMART

 SM01104; CTD 

PROSITE

  

PRINTS