UniProt Accession

 CETN2_MOUSE; Q9R1K9; B1AUQ6; B1AUQ8; Q3UBB4; Q9CWM0 

Genbank Protein ID

 AF080592; AL021127; AK004081; AK010541; AK140156; AK151033; AL671908; AL671908; CH466624; BC013545 

Genbank Nucleotide ID

 AAD46391.1; CAB88169.1; BAB23161.1; BAB27017.1; BAE24259.1; BAE30050.1; CAM20357.1; CAM20359.1; EDL26558.1; AAH13545.1 

Protein Name

 Centrin-2 

Protein Synonyms/Alias

 Caltractin isoform 1 

Gene Name

 Cetn2 

Gene Synonyms/Alias

 Calt 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
120	FDDDETGKISFKNLK	ubiquitination	[1]
124	ETGKISFKNLKRVAK	ubiquitination	[1]
131	KNLKRVAKELGENLT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110 (By similarity). 

Sequence Annotation

 DOMAIN 28 63 EF-hand 1.
 DOMAIN 64 99 EF-hand 2.
 DOMAIN 101 136 EF-hand 3.
 DOMAIN 137 172 EF-hand 4.
 REGION 1 25 Required for self-assembly (By
 MOD_RES 20 20 Phosphoserine.
 MOD_RES 26 26 Phosphothreonine.  

Keyword

 Calcium; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; DNA damage; DNA repair; Metal-binding; Mitosis; Nucleus; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0005814; C:centriole; IDA:MGI.
 GO:0005932; C:microtubule basal body; IDA:UniProtKB.
 GO:0032391; C:photoreceptor connecting cilium; IDA:MGI.
 GO:0071942; C:XPC complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0005509; F:calcium ion binding; TAS:MGI.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IDA:MGI.
 GO:0032795; F:heterotrimeric G-protein binding; IDA:MGI.
 GO:0008017; F:microtubule binding; IDA:MGI.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0007099; P:centriole replication; IEA:Compara.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0006289; P:nucleotide-excision repair; IEA:Compara.
 GO:0032465; P:regulation of cytokinesis; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEP:BHF-UCL. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000629; RNA-helicase_DEAD-box_CS. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS