CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038224
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cytosolic acyl coenzyme A thioester hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Acot7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
53RTRADHQKLGHCVTMacetylation[1, 2]
161GTKKLTNKATLWYVPacetylation[2]
161GTKKLTNKATLWYVPsuccinylation[2]
161GTKKLTNKATLWYVPubiquitination[3]
172WYVPLSLKNVDKVLEacetylation[4, 5]
172WYVPLSLKNVDKVLEubiquitination[3]
176LSLKNVDKVLEVPPIubiquitination[3]
287DAINFHDKIRKGCVIacetylation[5]
290NFHDKIRKGCVITISacetylation[2]
290NFHDKIRKGCVITISsuccinylation[2]
325PVVDNSQKRYRAASAubiquitination[3]
373KGRYLQMKAKRQGHTacetylation[2]
373KGRYLQMKAKRQGHTsuccinylation[2]
373KGRYLQMKAKRQGHTubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 384 AA 
Protein Sequence
MSAMKLLVGT LRLWEVGRQV AFSSLTPGQE CSGLRKTFWA AMRAVRTRAD HQKLGHCVTM 60
GRIMRPDDAN VAGNVHGGTI LKMIEEAGAI ISTRHCNSQN GERCVAALAR VERTDFLSPM 120
CIGEVAHVSA EITYTSKHSV EVQVHVMSEN ILTGTKKLTN KATLWYVPLS LKNVDKVLEV 180
PPIVYLRQEQ EEEGRKRYEA QKLERMETKW RNGDIVQPVL NPEPNTVSYS QSSLIHLVGP 240
SDCTLHGFVH GGVTMKLMDE VAGIVAARHC KTNIVTASVD AINFHDKIRK GCVITISGRM 300
TFTSNKSMEI EVLVDADPVV DNSQKRYRAA SAFFTYVSLN QEGKPMPVPQ LVPETEDEKK 360
RFEEGKGRYL QMKAKRQGHT EPQP 384 
Gene Ontology
 GO:0044297; C:cell body; IDA:MGI.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0043005; C:neuron projection; IDA:MGI.
 GO:0016290; F:palmitoyl-CoA hydrolase activity; IDA:MGI.
 GO:0009062; P:fatty acid catabolic process; IDA:MGI. 
Interpro
 IPR006683; Thioestr_supf. 
Pfam
 PF03061; 4HBT 
SMART
  
PROSITE
  
PRINTS