| Tag | Content |
|---|
| CPLM ID | CPLM-018786 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein FAN |
Protein Synonyms/Alias | Factor associated with neutral sphingomyelinase activation; Factor associated with N-SMase activation |
Gene Name | NSMAF |
Gene Synonyms/Alias | FAN |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 107 | SISQPIIKIPLRDCI | ubiquitination | [1] | | 115 | IPLRDCIKIGKHGEN | ubiquitination | [1] | | 399 | KPVGALNKERLERLL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. |
Sequence Annotation | DOMAIN 176 247 GRAM.
DOMAIN 290 575 BEACH.
REPEAT 628 658 WD 1.
REPEAT 670 700 WD 2.
REPEAT 712 740 WD 3.
REPEAT 761 791 WD 4.
REPEAT 803 833 WD 5.
REPEAT 884 914 WD 6. |
Keyword | Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 917 AA |
Protein Sequence | MTGQARFHRG AEACRAIRQC RSRRPRAAHP EGRAGSGRGS RHASPGVRRG GFSLLLLNLE 60
EYYFEQHRAN HILHKGSHHE RKIRGSLKIC SKSVIFEPDS ISQPIIKIPL RDCIKIGKHG 120
ENGANRHFTK AKSGGISLIF SQVYFIKEHN VVAPYKIERG KMEYVFELDV PGKVEDVVET 180
LLQLHRASCL DKLGDQTAMI TAILQSRLAR TSFDKNRFQN ISEKLHMECK AEMVTPLVTN 240
PGHVCITDTN LYFQPLNGYP KPVVQITLQD VRRIYKRRHG LMPLGLEVFC TEDDLCSDIY 300
LKFYEPQDRD DLYFYIATYL EHHVAEHTAE SYMLQWQRGH LSNYQYLLHL NNLADRSCND 360
LSQYPVFPWI IHDYSSSELD LSNPGTFRDL SKPVGALNKE RLERLLTRYQ EMPEPKFMYG 420
SHYSSPGYVL FYLVRIAPEY MLCLQNGRFD NADRMFNSIA ETWKNCLDGA TDFKELIPEF 480
YGDDVSFLVN SLKLDLGKRQ GGQMVDDVEL PPWASSPEDF LQKSKDALES NYVSEHLHEW 540
IDLIFGYKQK GSDAVGAHNV FHPLTYEGGV DLNSIQDPDE KVAMLTQILE FGQTPKQLFV 600
TPHPRRITPK FKSLSQTSSY NASMADSPGE ESFEDLTEES KTLAWNNITK LQLHEHYKIH 660
KEAVTGITVS RNGSSVFTTS QDSTLKMFSK ESKMLQRSIS FSNMALSSCL LLPGDATVIT 720
SSWDNNVYFY SIAFGRRQDT LMGHDDAVSK ICWHDNRLYS ASWDSTVKVW SGVPAEMPGT 780
KRHHFDLLAE LEHDVSVDTI SLNAASTLLV SGTKEGTVNI WDLTTATLMH QIPCHSGIVC 840
DTAFSPDSRH VLSTGTDGCL NVIDVQTGML ISSMTSDEPQ RCFVWDGNSV LSGSQSGELL 900
VWDLLGAKIS ERIQGHTGAV TCIWMNEQCS SIITGGEDRQ IIFWKLQY 948 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0005057; F:receptor signaling protein activity; TAS:ProtInc. GO:0006672; P:ceramide metabolic process; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |