UniProt Accession

 EXOS3_MOUSE; Q7TQK4; Q9CV81; Q9CVW2 

Genbank Protein ID

 BC023669; BC054085; AK006281; AK009165 

Genbank Nucleotide ID

 AAH23669.1; AAH54085.1; BAB24501.1; BAB26116.1 

Protein Name

 Exosome complex component RRP40 

Protein Synonyms/Alias

 Exosome component 3; Ribosomal RNA-processing protein 40 

Gene Name

 Exosc3 

Gene Synonyms/Alias

 Rrp40 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
150	LAFEGATKRNRPNVQ	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5 (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Exonuclease; Exosome; Hydrolase; Nuclease; Nucleus; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:Compara.
 GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.
 GO:0000176; C:nuclear exosome (RNase complex); IEA:Compara.
 GO:0005730; C:nucleolus; ISS:UniProtKB.
 GO:0035327; C:transcriptionally active chromatin; IEA:Compara.
 GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0071034; P:CUT catabolic process; IEA:Compara.
 GO:0045006; P:DNA deamination; IEA:Compara.
 GO:0043928; P:exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay; IEA:Compara.
 GO:0045190; P:isotype switching; IMP:UniProtKB.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0045830; P:positive regulation of isotype switching; IMP:MGI.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. 

Interpro

 IPR026699; Exosome_RNA_bind1/RRP40/RRP4. 

Pfam

  

SMART

  

PROSITE

  

PRINTS