CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010125
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytadherence high molecular weight protein 2 
Protein Synonyms/Alias
 Cytadherence accessory protein 2 
Gene Name
 hmw2 
Gene Synonyms/Alias
 MPN_310; MP526 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
117NNKARFFKDELKRLQacetylation[1]
331ASLANLTKEKERLSAacetylation[1]
391LKLETEHKQLQKRIGacetylation[1]
487IDEEQIFKLKEKIATacetylation[1]
501TERRELEKLYLVKKQacetylation[1]
522NDLLIFEKQLRQYQAacetylation[1]
551ASQKSLQKSFTQLKNacetylation[1]
578AEDWAHLKQNKHHHAacetylation[1]
695AERELAIKFKEKELEacetylation[1]
769QARLAEVKTLEKNQQacetylation[1]
781NQQETAAKSERELKVacetylation[1]
792ELKVALEKLNQAKKAacetylation[1]
863ALHSVKSKQELLEREacetylation[1]
1095QSNASLLKKRNQLTLacetylation[1]
1132IKEFLLEKKNFQKASacetylation[1]
1196KLQLEQFKLEKQNFDacetylation[1]
1214QKQLIEFKDQCQRLDacetylation[1]
1258SQQQLQHKYANLLELacetylation[1]
1266YANLLELKEKLQTAKacetylation[1]
1330QNLSSETKKKRQSLEacetylation[1]
1342SLEHDINKFDQRRKEacetylation[1]
1388QIEQEFSKLYQQREKacetylation[1]
1405RQRTTLSKLHRELKAacetylation[1]
1501QKQSIISKGQELKEIacetylation[1]
1568AKQKLSEKEARILKLacetylation[1]
1574EKEARILKLLEKMRAacetylation[1]
1693AKKNDFEKVEQMMQKacetylation[1]
1700KVEQMMQKLLEKTEQacetylation[1]
1704MMQKLLEKTEQKLSAacetylation[1]
1708LLEKTEQKLSAFDQKacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity). 
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Cytadherence; Phosphoprotein; Reference proteome; Virulence. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1818 AA 
Protein Sequence
MNDTDKKFPL QPVYDTGFDD GYLQRDYEKC LESAAANDAQ TVELQTQLLA EIKNLENEIK 60
ALKAQESRQP DPHNNARIQS LEASLNRLVN EYNNFEFQKN YMVDRVAELN NKARFFKDEL 120
KRLQQENAAF VNSRYANWAD FQSNYQLKLD QFQALIDQQN QTIKQLNEQI AANQGLIDQN 180
VQRLQQNHSL DQQERDALLY EVDHLYNELY ELENQKRLVG IEYEATYQDL VSADAELQNV 240
YETIAQNQAN FQKQCDAYWA QLKQVEQQIQ TTKQELVDEE STLKVRLNDA DFYINSRLAE 300
LDDLTSKINE RDFVSKEQAQ DVKASLANLT KEKERLSAEK DSFERLRNTA LNDINRMEQE 360
NALFAKHLEQ QQYEFERKQQ ESLLKLETEH KQLQKRIGEF KIESEAKSEA LLIQERELLE 420
KRREIDDLLT QASLEYEQQR RTNQVLKEKH RQVQQHFQNL VHAKKKLDQK RHYLAEQKRI 480
DEEQIFKLKE KIATERRELE KLYLVKKQKQ DQKENDLLIF EKQLRQYQAD FENEIEEKQN 540
ELFASQKSLQ KSFTQLKNKE AELNQKAQKI AEDWAHLKQN KHHHADLEIF LEGEFNHLQQ 600
EKHKLLEART QFDNRVSLLS ARFKQKQAEL VKQKQSLEQL TAAFNKEQEA VERDWKDRLA 660
NLEKQKEMLG DKVHQFDENS LNISKKLAER ELAIKFKEKE LEAAQKQLSL DNNNNAGLKL 720
QLDKLSESLK TERLELEASK ERILDFYDES SRRIADYESD LQARLAEVKT LEKNQQETAA 780
KSERELKVAL EKLNQAKKAF LQIRKQQLLE IASVKQQLAQ KANLLKNQQA ELDKQTEELE 840
AAFLEQDTDK KELEKALHSV KSKQELLERE RSFLLQKQRE FAEHVAGFKR QVHFKTTQMQ 900
RLSEFNKQQQ SEQIKRETEL KIAFADLKKD YQLFELQKNQ EFQQIEQKHK ELELLAQKQA 960
ELKQELEQKA TALASQDQDT VQAKLDLARQ QHELELRQNA FNQASLSLNK QREQLTNQVK 1020
VLHGELKKRH EKLTLKDRLL AEKEKDQHKK DAEINQRFKQ FENEYADFDQ AKKRELQELN 1080
QIRRNLEQSN ASLLKKRNQL TLDFALLRKV QHNTQTNRVQ LNTQIKEFLL EKKNFQKASD 1140
EAALQKALLI KRLRSFASKL QLQREALAIQ KLEFDKRDEQ QKSEINNAKL QLEQFKLEKQ 1200
NFDEAKQKQL IEFKDQCQRL DVEKRLLKQK LVQLKNLSKS YLTYKNRADL SQQQLQHKYA 1260
NLLELKEKLQ TAKRALDKKH RAIYGKMAQF VSELRQEKKQ LLSAQKQVDD KSRLLEQNQR 1320
HLQNLSSETK KKRQSLEHDI NKFDQRRKEA VSSILNSHKK LKQKEGELQG ILQKLSLKKT 1380
QIEQEFSKLY QQREKLDRQR TTLSKLHREL KAQNEATAHK NREVLEIENY YKKELQRLTT 1440
EKSEFDNNKN RLFEYFRKIR NEIEKKEAHI KTVLEETQKK RHLVETEAVK LHLQKQSIIS 1500
KGQELKEIKE RVSRDISHTN KQREELNSLL HQNKLLQKNL AEREREINNK DSLLTQKIQT 1560
AKQKLSEKEA RILKLLEKMR AVEQQYQAEI TRLKTRNADL EKNDNKHLFP PLFKINGNDM 1620
NYPYPYPWFY PQQKQEDSSN QIRHLFEQQL QFMQQRYENE LTELRRQRAL LEKKLDQIQL 1680
ESQLSAKKND FEKVEQMMQK LLEKTEQKLS AFDQKINALA EQINTQKAEH ADSEKQQLLL 1740
RIEQLEKQNL AQAVQTPQPV QPVVQAPAVV PQVIQPQVVQ SQPAFLATQQ SISKQQQIAQ 1800
LNAEINSIKK LIAQKAAK 1818 
Gene Ontology
 GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; IEA:UniProtKB-KW.
 GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR016430; Cytadherence_Hmw2. 
Pfam
  
SMART
  
PROSITE
  
PRINTS