CPLM-011395

Genbank Nucleotide ID

U6 snRNA-associated Sm-like protein LSm6

Protein Synonyms/Alias

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Position	Peptide	Type	References
66	NNNKLLNKFNSDVFL	acetylation	[1]

[1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]

Functional Description

Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. In association with PAT1, LSM1-LSM7 binds directly to RNAs near the 3'-end and prefers oligoadenylated RNAs over polyadenylated RNAs. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. Component of a nucleolar LSM2-LSM7 complex, which associates with the precursor of the RNA component of RNase P (pre-P RNA) and with the small nucleolar RNA (snoRNA) snR5. It may play a role in the maturation of a subset of nucleolus-associated small RNAs.

Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; rRNA processing; Spliceosome; tRNA processing.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0000932; C:cytoplasmic mRNA processing body; IDA:SGD.
GO:0005730; C:nucleolus; IDA:SGD.
GO:0005732; C:small nucleolar ribonucleoprotein complex; IPI:SGD.
GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD.
GO:0005688; C:U6 snRNP; IDA:SGD.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0030490; P:maturation of SSU-rRNA; IMP:SGD.
GO:0000398; P:mRNA splicing, via spliceosome; IPI:SGD.
GO:0000956; P:nuclear-transcribed mRNA catabolic process; TAS:SGD.
GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.

IPR010920; LSM_dom.
IPR001163; Ribonucl_LSM.
IPR006649; Ribonucl_LSM_euk/arc.