CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012186
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin alpha-7 
Protein Synonyms/Alias
 Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form 
Gene Name
 ITGA7 
Gene Synonyms/Alias
 UNQ406/PRO768 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1051VPQYHAVKIPREDRQubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. 
Sequence Annotation
 REPEAT 35 103 FG-GAP 1.
 REPEAT 110 175 FG-GAP 2.
 REPEAT 185 238 FG-GAP 3.
 REPEAT 292 350 FG-GAP 4.
 REPEAT 351 411 FG-GAP 5.
 REPEAT 412 467 FG-GAP 6.
 REPEAT 471 530 FG-GAP 7.
 REPEAT 1157 1160 1.
 REPEAT 1165 1168 2.
 REPEAT 1173 1176 3.
 REGION 1157 1176 3 X 4 AA repeats of D-X-H-P.
 MOTIF 1107 1111 GFFKR motif.
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
 CARBOHYD 786 786 N-linked (GlcNAc...) (Potential).
 CARBOHYD 989 989 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1025 1025 N-linked (GlcNAc...).
 CARBOHYD 1045 1045 N-linked (GlcNAc...) (Potential).
 DISULFID 94 103 By similarity.
 DISULFID 140 163 By similarity.
 DISULFID 184 197 By similarity.
 DISULFID 539 546 By similarity.
 DISULFID 552 615 By similarity.
 DISULFID 681 687 By similarity.
 DISULFID 781 792 By similarity.
 DISULFID 939 994 Interchain (between heavy and light
 DISULFID 1001 1006 By similarity.  
Keyword
 ADP-ribosylation; Alternative splicing; Calcium; Cell adhesion; Cell shape; Cleavage on pair of basic residues; Complete proteome; Congenital muscular dystrophy; Direct protein sequencing; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1181 AA 
Protein Sequence
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 60
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 120
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 180
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH 240
LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 300
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL 360
TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS 420
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI 480
KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA 540
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 600
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP 660
ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT REKPLCLSNE NASHVECELG 720
NPMKRGAQVT FYLILSTSGI SIETTELEVE LLLATISEQE LHPVSARARV FIELPLSIAG 780
MAIPQQLFFS GVVRGERAMQ SERDVGSKVK YEVTVSNQGQ SLRTLGSAFL NIMWPHEIAN 840
GKWLLYPMQV ELEGGQGPGQ KGLCSPRPNI LHLDVDSRDR RRRELEPPEQ QEPGERQEPS 900
MSWWPVSSAE KKKNITLDCA RGTANCVVFS CPLYSFDRAA VLHVWGRLWN STFLEEYSAV 960
KSLEVIVRAN ITVKSSIKNL MLRDASTVIP VMVYLDPMAV VAEGVPWWVI LLAVLAGLLV 1020
LALLVLLLWK MGFFKRAKHP EATVPQYHAV KIPREDRQQF KEEKTGTILR NNWGSPRREG 1080
PDAHPILAAD GHPELGPDGH PGPGTA 1106 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0008305; C:integrin complex; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0048514; P:blood vessel morphogenesis; IEA:Compara.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007517; P:muscle organ development; TAS:ProtInc.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara. 
Interpro
 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 
Pfam
 PF01839; FG-GAP
 PF08441; Integrin_alpha2 
SMART
 SM00191; Int_alpha 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA 
PRINTS
 PR01185; INTEGRINA.