UniProt Accession

 DTD1_HUMAN; Q8TEA8; A8K5X5; D3DW37; Q496D1; Q5W184; Q8WXU8; Q9BW67; Q9H464; Q9H474 

Genbank Protein ID

 AF332356; AK074304; AK291440; AL121900; AL121780; AL121780; AL121900; CH471133; BC000599; CH471133; BC045167; BC100923; BC100924; BC100925 

Genbank Nucleotide ID

 AAL57046.1; BAB85044.1; BAF84129.1; CAH73147.1; CAH73147.1; CAI15669.1; CAI15669.1; EAX10227.1; EAX10228.1; AAH45167.1; AAI00924.1; AAI00925.1; AAI00926.1 

Protein Name

 D-tyrosyl-tRNA(Tyr) deacylase 1 

Protein Synonyms/Alias

 Histidyl-tRNA synthase-related 

Gene Name

 DTD1 

Gene Synonyms/Alias

 C20orf88; HARS2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
61	VFEDESGKHWSKSVM	acetylation	[1]
65	ESGKHWSKSVMDKQY	acetylation	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential). 

Sequence Annotation

 ACT_SITE 81 81 Nucleophile (By similarity).
 MOD_RES 196 196 Phosphoserine (By similarity).
 MOD_RES 197 197 Phosphoserine.
 MOD_RES 205 205 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
 GO:0019478; P:D-amino acid catabolic process; IEA:InterPro. 

Interpro

 IPR023509; DTD-like_dom.
 IPR003732; DTyrtRNA_deacyls. 

Pfam

 PF02580; Tyr_Deacylase 

SMART

  

PROSITE

  

PRINTS