UniProt Accession

 PA1B2_HUMAN; P68402; A8DPS5; A8DPS6; A8DPS7; E9PEJ5; E9PLP3; O00687; Q29459; Q6IBR6 

Genbank Protein ID

 D63390; DQ836738; DQ836739; DQ836740; DQ836741; DQ836742; DQ836743; AK292973; CR456736; EF445007; AP005018; CH471065; BC000398; BC019301 

Genbank Nucleotide ID

 BAA19917.1; ABI58225.1; ABI58226.1; ABI58227.1; ABI58228.1; ABI58229.1; ABI58230.1; BAF85662.1; CAG33017.1; ACA06040.1; EAW67281.1; AAH00398.1; AAH19301.1 

Protein Name

 Platelet-activating factor acetylhydrolase IB subunit beta 

Protein Synonyms/Alias

 PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta 

Gene Name

 PAFAH1B2 

Gene Synonyms/Alias

 PAFAHB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	RHVLWRLKNGELENI	ubiquitination	[1]
133	NTRQPQAKIIVLGLL	ubiquitination	[2, 3]
207	GGYAKICKPLHELIM	ubiquitination	[4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865] 

Functional Description

 Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit. 

Sequence Annotation

 ACT_SITE 48 48 By similarity.
 ACT_SITE 193 193 By similarity.
 ACT_SITE 196 196 By similarity.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; TAS:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IEA:EC.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc.
 GO:0016239; P:positive regulation of macroautophagy; IMP:BHF-UCL.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR013831; SGNH_hydro-type_esterase_dom. 

Pfam

  

SMART

  

PROSITE

 PS01098; LIPASE_GDSL_SER 

PRINTS