CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007103
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit delta 
Protein Synonyms/Alias
 TCP-1-delta; CCT-delta 
Gene Name
 CCT4 
Gene Synonyms/Alias
 ANC2; TCP4; YDL143W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
129DSFQSAAKRSVDILLacetylation[1]
187KISDENSKNVDLNDIubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation. 
Sequence Annotation
  
Keyword
 3D-structure; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 528 AA 
Protein Sequence
MSAKVPSNAT FKNKEKPQEV RKANIIAARS VADAIRTSLG PKGMDKMIKT SRGEIIISND 60
GHTILKQMAI LHPVARMLVE VSAAQDSEAG DGTTSVVILT GALLGAAERL LNKGIHPTII 120
ADSFQSAAKR SVDILLEMCH KVSLSDREQL VRAASTSLSS KIVSQYSSFL APLAVDSVLK 180
ISDENSKNVD LNDIRLVKKV GGTIDDTEMI DGVVLTQTAI KSAGGPTRKE KAKIGLIQFQ 240
ISPPKPDTEN NIIVNDYRQM DKILKEERAY LLNICKKIKK AKCNVLLIQK SILRDAVNDL 300
ALHFLSKLNI MVVKDIEREE IEFLSKGLGC KPIADIELFT EDRLGSADLV EEIDSDGSKI 360
VRVTGIRNNN ARPTVSVVIR GANNMIIDET ERSLHDALCV IRCLVKERGL IAGGGAPEIE 420
ISRRLSKEAR SMEGVQAFIW QEFASALEVI PTTLAENAGL NSIKVVTELR SKHENGELND 480
GISVRRSGTT NTYEEHILQP VLVSTSAITL ASECVKSILR IDDIAFSR 528 
Gene Ontology
 GO:0005832; C:chaperonin-containing T-complex; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051082; F:unfolded protein binding; IDA:SGD.
 GO:0006457; P:protein folding; IDA:SGD. 
Interpro
 IPR012717; Chap_CCT_delta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.