CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008673
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 
Protein Synonyms/Alias
 Succinyl-CoA synthetase beta chain; SCS-beta 
Gene Name
 LSC2 
Gene Synonyms/Alias
 YGR244C; G8625 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
121LNHNLITKQTGIAGKacetylation[1]
216DAQDEAAKAVSNLYKacetylation[1]
268NASFRQEKIYSWRDLacetylation[1]
284QEDPDEVKAKKYDLNubiquitination[2]
287PDEVKAKKYDLNFVKacetylation[1]
393VARLQGTKVEEGRDIacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
  
Sequence Annotation
 DOMAIN 39 267 ATP-grasp.
 MOD_RES 102 102 Phosphoserine.
 MOD_RES 263 263 Phosphoserine.
 MOD_RES 276 276 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 427 AA 
Protein Sequence
MYSRKSLSLI SKCGQLSRLN AQAALQARRH LSIHEYRSAQ LLREYGIGTP EGFPAFTPEE 60
AFEAAKKLNT NKLVIKAQAL TGGRGKGHFD TGYKSGVHMI ESPQQAEDVA KEMLNHNLIT 120
KQTGIAGKPV SAVYIVKRVD TKHEAYLSIL MDRQTKKPMI IASSQGGMNI EEVAERTPDA 180
IKKFSIETSK GLSPQMAKDV AKSLGFSPDA QDEAAKAVSN LYKIFMERDA TQVEINPLSE 240
IEHDPTHKIM CTDAKFGFDD NASFRQEKIY SWRDLSQEDP DEVKAKKYDL NFVKLKGNIG 300
CLVNGAGLAM ATMDVIKLNG GDPANFLDCG GGATPETIKQ GFELILSNKN VDAIFVNIFG 360
GIVRCDYVAL GLVEAARELE VRVPIVARLQ GTKVEEGRDI INKSGVKIYS FDELDPAAKK 420
VVELTQN 427 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IMP:SGD.
 GO:0006104; P:succinyl-CoA metabolic process; IDA:SGD.
 GO:0006099; P:tricarboxylic acid cycle; TAS:SGD. 
Interpro
 IPR013650; ATP-grasp_succ-CoA_synth-type.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR005811; CoA_ligase.
 IPR017866; Succ-CoA_synthase_bsu_CS.
 IPR005809; Succ_CoA_synthase_bsu.
 IPR016102; Succinyl-CoA_synth-like. 
Pfam
 PF08442; ATP-grasp_2
 PF00549; Ligase_CoA 
SMART
  
PROSITE
 PS50975; ATP_GRASP
 PS01217; SUCCINYL_COA_LIG_3 
PRINTS