UniProt Accession

 SNP25_RAT; P60881; P13795; P36974; P70557; P70558; Q8IXK3; Q96FM2; Q9BR45 

Genbank Protein ID

 AB003991; AB003992; AF245227; U56262; BC087699; U56261 

Genbank Nucleotide ID

 BAA20151.1; BAA20152.1; AAF81202.1; AAA99826.1; AAH87699.1; AAA99825.1 

Protein Name

 Synaptosomal-associated protein 25 

Protein Synonyms/Alias

 SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa protein 

Gene Name

 Snap25 

Gene Synonyms/Alias

 Snap 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
40	LQLVEESKDAGIRTL	ubiquitination	[1]
69	EGMDQINKDMKEAEK	ubiquitination	[1]
72	DQINKDMKEAEKNLT	ubiquitination	[1]
76	KDMKEAEKNLTDLGK	ubiquitination	[1]
103	KSSDAYKKAWGNNQD	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. 

Sequence Annotation

 DOMAIN 19 81 t-SNARE coiled-coil homology 1.
 DOMAIN 140 202 t-SNARE coiled-coil homology 2.
 REGION 1 75 Interaction with CENPF (By similarity).
 MOD_RES 138 138 Phosphothreonine; by PKC and PKA.
 MOD_RES 187 187 Phosphoserine; by PKC.
 LIPID 85 85 S-palmitoyl cysteine (By similarity).
 LIPID 88 88 S-palmitoyl cysteine (By similarity).
 LIPID 90 90 S-palmitoyl cysteine (By similarity).
 LIPID 92 92 S-palmitoyl cysteine (By similarity).  

Keyword

 3D-structure; Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Repeat; Synapse; Synaptosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:RGD.
 GO:0044295; C:axonal growth cone; IDA:MGI.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005768; C:endosome; IDA:RGD.
 GO:0030175; C:filopodium; IDA:RGD.
 GO:0030027; C:lamellipodium; IDA:RGD.
 GO:0045121; C:membrane raft; IDA:RGD.
 GO:0043025; C:neuronal cell body; IDA:RGD.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; IDA:MGI.
 GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IDA:MGI.
 GO:0070033; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex; IDA:RGD.
 GO:0008076; C:voltage-gated potassium channel complex; IDA:RGD.
 GO:0005484; F:SNAP receptor activity; TAS:RGD.
 GO:0017075; F:syntaxin-1 binding; IDA:MGI.
 GO:0005249; F:voltage-gated potassium channel activity; IDA:RGD.
 GO:0007409; P:axonogenesis; IEP:RGD.
 GO:0048791; P:calcium ion-dependent exocytosis of neurotransmitter; IDA:RGD.
 GO:0016197; P:endosomal transport; IDA:RGD.
 GO:0006887; P:exocytosis; TAS:RGD.
 GO:0030252; P:growth hormone secretion; IEP:RGD.
 GO:0007616; P:long-term memory; IMP:RGD.
 GO:0032024; P:positive regulation of insulin secretion; IEP:RGD.
 GO:0051963; P:regulation of synapse assembly; IEP:RGD.
 GO:0030431; P:sleep; IDA:RGD. 

Interpro

 IPR000928; SNAP-25.
 IPR000727; T_SNARE_dom. 

Pfam

 PF00835; SNAP-25
 PF05739; SNARE 

SMART

 SM00397; t_SNARE 

PROSITE

 PS50192; T_SNARE 

PRINTS