UniProt Accession

 NIT1_HUMAN; Q86X76; B1AQP3; D3DVF4; O76091 

Genbank Protein ID

 AF069984; AF069987; CR541814; CR541846; AL591806; CH471121; CH471121; CH471121; BC046149 

Genbank Nucleotide ID

 AAC39901.1; AAC39907.1; CAG46613.1; CAG46644.1; CAI15379.1; EAW52656.1; EAW52654.1; EAW52657.1; AAH46149.1 

Protein Name

 Nitrilase homolog 1 

Protein Synonyms/Alias

  

Gene Name

 NIT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
108	LSEPLGGKLLEEYTQ	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity). 

Sequence Annotation

 DOMAIN 47 320 CN hydrolase.
 ACT_SITE 86 86 Proton acceptor (Potential).
 ACT_SITE 161 161 By similarity.
 ACT_SITE 203 203 Nucleophile (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Mitochondrion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0000257; F:nitrilase activity; TAS:ProtInc.
 GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro. 

Interpro

 IPR003010; C-N_Hydrolase.
 IPR001110; UPF0012_CS. 

Pfam

 PF00795; CN_hydrolase 

SMART

  

PROSITE

 PS50263; CN_HYDROLASE
 PS01227; UPF0012 

PRINTS