CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020653
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 28S ribosomal protein S22, mitochondrial 
Protein Synonyms/Alias
 MRP-S22; S22mt 
Gene Name
 Mrps22 
Gene Synonyms/Alias
 Rpms22 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
98RPAIQPLKPPTYKLMacetylation[1]
257EDIDRHGKYELLRSTacetylation[2, 3]
277MAWYFVNKKKIDGLLacetylation[1]
332DLIKVFAKTEAQRGAacetylation[4]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753
Functional Description
  
Sequence Annotation
 MOD_RES 210 210 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MAAVRTPLSL WRFQLGSRRA RRVCTRATAQ RHPDALLATR PQPFEVGQPR RLLSSEAESG 60
SSEVKKPAFM DEEVQRILTK ITGLDLQKTF RPAIQPLKPP TYKLMTQAQL EEATRLAVEA 120
AKVRLKMPPV LEERKPINDV LAEDKILEGT ETNKYVFTDI SYNIPHRERF IVVREPSGTL 180
RKASWEERDR VIQIYFPKEG RRVLPPVIFK DENLKTMYSQ DRHADVLNLC VAQFEPDSAE 240
YIKVHHQTYE DIDRHGKYEL LRSTRHFGGM AWYFVNKKKI DGLLIDQIQR DLVDDATSLV 300
QLYHMLHPDG QSAQEAKEQA AEGVDLIKVF AKTEAQRGAY IELALQTYQE IVTSHSAAS 359 
Gene Ontology
 GO:0005763; C:mitochondrial small ribosomal subunit; ISO:MGI.
 GO:0003735; F:structural constituent of ribosome; ISO:MGI. 
Interpro
 IPR019374; Ribosomal_S22_mit. 
Pfam
 PF10245; MRP-S22 
SMART
  
PROSITE
  
PRINTS