CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010102
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Probable lipoate-protein ligase A 
Protein Synonyms/Alias
 Lipoate--protein ligase 
Gene Name
 lplA 
Gene Synonyms/Alias
 MPN_389; MP449 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
96SIILPKAKKEMENAYacetylation[1]
112ETTRNVVKFLNSVGVacetylation[1]
134NDLEIEGKKFSGLAEacetylation[1]
145GLAEYLSKDRVLVHGacetylation[1]
165TDFTKLAKYLNVDKTacetylation[1]
171AKYLNVDKTKMVSKGacetylation[1]
177DKTKMVSKGIESVQKacetylation[1]
184KGIESVQKRVVNVKEacetylation[1]
230SSIKMVEKRAQEHFQacetylation[1]
252KTADYNFKNKKRFEGacetylation[1]
308YDYQTFAKILGNIDNacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819
Functional Description
 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity). 
Sequence Annotation
 NP_BIND 77 80 ATP (By similarity).
 BINDING 72 72 ATP (By similarity).
 BINDING 135 135 ATP (By similarity).
 BINDING 135 135 Lipoate (By similarity).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MKTYILTSPK NIPYFNAALE EWLLTEFKKG EEIKVIYFWQ NANTIVVGRN QNTYAEVNLS 60
EVEKDKVNLF RRFSGGGAVF HDMGNICFSI ILPKAKKEME NAYEETTRNV VKFLNSVGVP 120
AQFHGRNDLE IEGKKFSGLA EYLSKDRVLV HGTLLFDTDF TKLAKYLNVD KTKMVSKGIE 180
SVQKRVVNVK EYLPNLSTPT FLEKMVQFFT ETEHAETIHL DESSIKMVEK RAQEHFQSWD 240
WNFGKTADYN FKNKKRFEGA GIFECNVQVD QGKVVDIKFY GDFLSVIDIT PVTQQLVGQK 300
YDYQTFAKIL GNIDNFKEYF GTLTPQQMLE VIFDNKKDE 339 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
 GO:0009249; P:protein lipoylation; IEA:InterPro. 
Interpro
 IPR004143; BPL_LipA_LipB.
 IPR019491; Lipoate_protein_ligase_C.
 IPR004562; LipoylTrfase_LipoateP_Ligase. 
Pfam
 PF03099; BPL_LplA_LipB
 PF10437; Lip_prot_lig_C 
SMART
  
PROSITE
  
PRINTS