CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042647
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alcohol dehydrogenase class-3 
Protein Synonyms/Alias
  
Gene Name
 ADH5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
107KIRVTQGKGLMPDGTubiquitination[1, 2]
213IIGVDINKDKFARAKacetylation[3]
213IIGVDINKDKFARAKubiquitination[1, 2]
215GVDINKDKFARAKEFacetylation[2]
215GVDINKDKFARAKEFubiquitination[1, 2]
220KDKFARAKEFGATECubiquitination[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Oxidoreductase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 262 AA 
Protein Sequence
VIKCKAAVAW EAGKPLSIEE IEVAPPKAHE VRIKIIATAV CHTDAYTLSG ADPEGCFPVI 60
LGHEGAGIVE SVGDTVIPLY IPQCGECKFC LNPKTNLCQK IRVTQGKGLM PDGTSRFTCK 120
GKTILHYMGT STFSEYTVVA DISVAKIDPL APLDKVCLLG CGISTGYGAA VNTAKLEPGS 180
VCAVFGLGGV GLAVIMGCKV AGASRIIGVD INKDKFARAK EFGATECINP QDFSKPIQEV 240
LIEMTDGGVD YSFECIGNVK VM 262 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF08240; ADH_N
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
 PS00059; ADH_ZINC 
PRINTS