UniProt Accession

 DOK2_HUMAN; O60496; Q8N5A4 

Genbank Protein ID

 AF034970; BC032623 

Genbank Nucleotide ID

 AAC13265.1; AAH32623.1 

Protein Name

 Docking protein 2 

Protein Synonyms/Alias

 Downstream of tyrosine kinase 2; p56(dok-2) 

Gene Name

 DOK2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MGDGAVKQGFLYLQ	ubiquitination	[1, 2]
312	AVARSLGKNFRGILA	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). 

Sequence Annotation

 DOMAIN 4 114 PH.
 DOMAIN 147 252 IRS-type PTB.
 MOD_RES 271 271 Phosphotyrosine (By similarity).
 MOD_RES 299 299 Phosphotyrosine.
 MOD_RES 345 345 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005057; F:receptor signaling protein activity; IEA:Compara.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0007265; P:Ras protein signal transduction; IEA:Compara.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Compara. 

Interpro

 IPR002404; Insln_rcpt_S1.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 

Pfam

 PF02174; IRS 

SMART

 SM00233; PH
 SM00310; PTBI 

PROSITE

 PS51064; IRS_PTB
 PS50003; PH_DOMAIN 

PRINTS