Tag | Content |
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CPLM ID | CPLM-016793 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RING1 and YY1-binding protein |
Protein Synonyms/Alias | Death effector domain-associated factor; DED-associated factor |
Gene Name | Rybp |
Gene Synonyms/Alias | Dedaf |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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136 | QSANATTKTSETNHT | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity). |
Sequence Annotation | ZN_FING 21 50 RanBP2-type. REGION 143 226 Interaction with E4TF1B (By similarity). MOD_RES 99 99 Phosphoserine (By similarity). MOD_RES 127 127 Phosphoserine (By similarity). MOD_RES 130 130 Phosphoserine (By similarity). MOD_RES 227 227 Phosphoserine (By similarity). |
Keyword | Apoptosis; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 228 AA |
Protein Sequence | MTMGDKKSPT RPKRQAKPAA DEGFWDCSVC TFRNSAEAFK CSICDVRKGT STRKPRINSQ 60 LVAQQVAQQY ATPPPPKKEK KEKVEKPDKE KPEKDKDISP SVTKKNTNKK TKPKSDILKD 120 PPSEANSIQS ANATTKTSET NHTSRPRLKN VDRSTAQQLA VTVGNVTVII TDFKEKTRSS 180 STSSSTVTSS AGSEQQNQSS SGSESTDKGS SRSSTPKGDM SAVNDESF 228 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005654; C:nucleoplasm; IDA:MGI. GO:0031519; C:PcG protein complex; IEA:Compara. GO:0003677; F:DNA binding; IDA:MGI. GO:0003714; F:transcription corepressor activity; IDA:MGI. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0035518; P:histone H2A monoubiquitination; IEA:Compara. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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