CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021734
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vesicle-associated membrane protein 7 
Protein Synonyms/Alias
 VAMP-7; Synaptobrevin-like protein 1 
Gene Name
 Vamp7 
Gene Synonyms/Alias
 Sybl1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
137QAQVDELKGIMVRNIubiquitination[1]
172VDSSVTFKTTSRNLAubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. 
Sequence Annotation
 DOMAIN 7 110 Longin.
 DOMAIN 125 185 v-SNARE coiled-coil homology.
 MOD_RES 2 2 N-acetylalanine (By similarity).  
Keyword
 Acetylation; Cell junction; Coiled coil; Complete proteome; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome; Exocytosis; Golgi apparatus; Lysosome; Membrane; Protein transport; Reference proteome; Signal-anchor; Synapse; Synaptosome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 220 AA 
Protein Sequence
MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY LFHYICQDRI 60
VYLCITDDDF ERSRAFGFLN EVKKRFQTTY GSRAQTALPY AMNSEFSSVL AAQLKHHSEN 120
QSLDRVTETQ AQVDELKGIM VRNIDLVAQR GERLELLIDK TENLVDSSVT FKTTSRNLAR 180
AMCVKNVKLT AIIVVVSIVF IYIIVSPLCG GFTWPSCVKK 220 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IDA:UniProtKB.
 GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
 GO:0043005; C:neuron projection; ISS:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0045335; C:phagocytic vesicle; ISS:UniProtKB.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0031201; C:SNARE complex; IDA:UniProtKB.
 GO:0045202; C:synapse; IEA:UniProtKB-KW.
 GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0017156; P:calcium ion-dependent exocytosis; IDA:UniProtKB.
 GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB.
 GO:0043308; P:eosinophil degranulation; IDA:UniProtKB.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IDA:UniProtKB.
 GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara.
 GO:0043312; P:neutrophil degranulation; IDA:UniProtKB.
 GO:0006911; P:phagocytosis, engulfment; IDA:UniProtKB.
 GO:1900483; P:regulation of protein targeting to vacuolar membrane; IEA:Compara.
 GO:0034197; P:triglyceride transport; IMP:RGD.
 GO:0048280; P:vesicle fusion with Golgi apparatus; IDA:RGD. 
Interpro
 IPR011012; Longin-like_dom.
 IPR010908; Longin_dom.
 IPR001388; Synaptobrevin. 
Pfam
 PF13774; Longin
 PF00957; Synaptobrevin 
SMART
  
PROSITE
 PS50859; LONGIN
 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 
PRINTS
 PR00219; SYNAPTOBREVN.