| Tag | Content |
|---|
| CPLM ID | CPLM-013104 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleckstrin homology domain-containing family A member 7 |
Protein Synonyms/Alias | PH domain-containing family A member 7; Heart adapter protein 1 |
Gene Name | Plekha7 |
Gene Synonyms/Alias | Hadp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 172 | VVRGWLHKQDSSGMR | ubiquitination | [1] | | 472 | ENYQSLPKSTRHLSG | ubiquitination | [1] | | 493 | RNLPSDYKYAQDRAS | ubiquitination | [1] | | 647 | SAPSLHGKSADDTYL | ubiquitination | [1] | | 657 | DDTYLQLKKDLEYLD | ubiquitination | [1] | | 658 | DTYLQLKKDLEYLDL | ubiquitination | [1] | | 666 | DLEYLDLKMTGRDLL | ubiquitination | [1] | | 716 | IRALKENKDQLESVL | ubiquitination | [1] | | 742 | DQPQHLEKITCQQRL | ubiquitination | [1] | | 802 | RAFFFQEKSQIQKDL | ubiquitination | [1] | | 807 | QEKSQIQKDLWRIED | ubiquitination | [1] | | 1097 | RTLSQGEKTGLLSAR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). |
Sequence Annotation | DOMAIN 8 41 WW 1.
DOMAIN 53 86 WW 2.
DOMAIN 163 281 PH.
REGION 535 693 Interaction with CTNND1 (By similarity).
MOD_RES 364 364 Phosphotyrosine.
MOD_RES 533 533 Phosphoserine.
MOD_RES 542 542 Phosphoserine.
MOD_RES 601 601 Phosphoserine (By similarity).
MOD_RES 609 609 Phosphoserine.
MOD_RES 900 900 Phosphoserine.
MOD_RES 904 904 Phosphoserine.
MOD_RES 983 983 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Cell junction; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1118 AA |
Protein Sequence | MAAAVGRDTL PEHWSYGVCR DGRVFFINDQ LRCTTWLHPR TGEPVNSGHM IRSDLPRGWE 60
EGFTEEGASF FIDHNQQTTT FRHPVTGQFS SENSEYVLRE EPHPHMSKPE RNQRPSSMVS 120
ETSTAGTTST LEAKPGPKIV KSSSKVHSFG KRDQAIRRNL NVPVVVRGWL HKQDSSGMRL 180
WKRRWFVLAD YCLFYYKDSR EEAVLGSIPL PSYVISPVAP EDRISRKYSF KAVHTGMRAL 240
IYSTTTAGSQ MEHSGMRTYY FSADTLEDMN AWVRAMNQAA QVLSRSSLRR DVDKVERQAM 300
PQANHTDACQ ECGHVGPGHS RDCPRRGYED SYGFNRREQE EERFRAQRDP LEGRRDRSKA 360
RSPYLPAEED ALFVDLPGGP RGQQAQPQRA EKNGVPPYGL GEQNGTNGYQ RTAPPRANPE 420
KHSQRKTGLA QAEHWTKAQK GDGRSLPLDQ TLPRQGPSQP LSFPENYQSL PKSTRHLSGS 480
SSPPPRNLPS DYKYAQDRAS HLKMSSEERR AHRDGTVWQL YEWQQRQQFR HGSPTAPIGA 540
GSPEFTEQGR SRSLLEVPRS ISVPPSPSDI PPPGPPRPFP PRRPHTPAER VTVKPPEQRR 600
SVDISLGGSP RKARGHAAKN SSHVDRRSMP SMGYMTHTVS APSLHGKSAD DTYLQLKKDL 660
EYLDLKMTGR DLLKDRSLKP MKIAESDIDV KLSIFCEQDR ILQDLEDKIR ALKENKDQLE 720
SVLEVLHRQT EQYRDQPQHL EKITCQQRLL QEDLVHIRAE LCRESTEMEN AWNEYLKLEK 780
DVEQLKQTLQ EQHRRAFFFQ EKSQIQKDLW RIEDVMAGLS ANKENYRVLV GSVKNPERKT 840
VPLFPHPSVP SLSPTESKPA LQPSPPTSPV RTPLEVRLFP QLQTYVPYRP HPPQLRKVMS 900
PLQSPTKAKP QAEDEAPPRP PLPELYSPED QPPAVPPLPR EATIIRHTSV RGLKRQSDER 960
KRDREQGQCV NGDLKVELRS YVSEPELASL SGDVPQPSLS LVGSESRYQT LPGRGLSGST 1020
SRLQQSSTIA PYVTLRRGLN AENSSATFSR PKSALERLYS GDHQRGKMSA EEQLERMKRH 1080
QKALVRERKR TLSQGEKTGL LSARYLSQPL PGDLGSVC 1118 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |