CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leukocyte elastase inhibitor A 
Protein Synonyms/Alias
 Serine protease inhibitor EIA; Serpin B1a 
Gene Name
 Serpinb1a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
177MWEEKFMKQDTTDAPacetylation[1]
260EKLREWTKRENLENIacetylation[1]
317SRDLFISKIVHKAFVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Regulates the activity of the neutrophil proteases (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Protease inhibitor; Reference proteome; Serine protease inhibitor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 379 AA 
Protein Sequence
MEQLSSANSL FALELFHTLS ESSPTGNIFF SPFSISSALA MVFLGTKGTT AAQLSKTFHF 60
DSVEDVHSRF QSLNAEVSKR GASHTLKLAN RLYGEKTYNF LPEFLTSTQK MYGADLAPVD 120
FQHASEDARK EINQWVKGQT EGKIPELLAV GVVDSMTKLV LVNAIYFKGM WEEKFMKQDT 180
TDAPFRLNKK NTKSVKMMYQ KKKFFFGYIS DLKCKVLEMP YQGGELSMVI LLPEDIEDES 240
TGLKKIEEQI TLEKLREWTK RENLENIDVH VKLPRFKIEE SYILNSNLGR LGLQDLFNSS 300
KADLSGMSGS RDLFISKIVH KAFVEVNEEG TEAAAATAGI ATFCMLLPEE EFTADHPFIF 360
FIRHNPTANV LFLGRVCSP 379 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IBA:RefGenome.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0042176; P:regulation of protein catabolic process; IEA:Compara.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 
Interpro
 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR015557; Protease_inhib_serpin_B1.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00284; SERPIN 
PRINTS