CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002646
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-N-acetylenolpyruvoylglucosamine reductase 
Protein Synonyms/Alias
 UDP-N-acetylmuramate dehydrogenase 
Gene Name
 murB 
Gene Synonyms/Alias
 yijB; b3972; JW3940 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
164GYRDSIFKHEYQDRFacetylation[1]
217VCHMRTTKLPDPKVNacetylation[1]
222TTKLPDPKVNGNAGSacetylation[1]
242VVSAETAKALLSQFPacetylation[1]
299LINEDNAKSEDVVQLacetylation[1]
317VRQKVGEKFNVWLEPacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Cell wall formation. 
Sequence Annotation
 DOMAIN 13 183 FAD-binding PCMH-type.
 ACT_SITE 159 159
 ACT_SITE 229 229 Proton donor.
 ACT_SITE 325 325
 BINDING 190 190 Substrate.  
Keyword
 3D-structure; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Peptidoglycan synthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 342 AA 
Protein Sequence
MNHSLKPWNT FGIDHNAQHI VCAEDEQQLL NAWQYATAEG QPVLILGEGS NVLFLEDYRG 60
TVIINRIKGI EIHDEPDAWY LHVGAGENWH RLVKYTLQEG MPGLENLALI PGCVGSSPIQ 120
NIGAYGVELQ RVCAYVDSVE LATGKQVRLT AKECRFGYRD SIFKHEYQDR FAIVAVGLRL 180
PKEWQPVLTY GDLTRLDPTT VTPQQVFNAV CHMRTTKLPD PKVNGNAGSF FKNPVVSAET 240
AKALLSQFPT APNYPQADGS VKLAAGWLID QCQLKGMQIG GAAVHRQQAL VLINEDNAKS 300
EDVVQLAHHV RQKVGEKFNV WLEPEVRFIG ASGEVSAVET IS 342 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0050660; F:flavin adenine dinucleotide binding; IDA:EcoliWiki.
 GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IDA:EcoCyc.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0071555; P:cell wall organization; IMP:EcoliWiki.
 GO:0009252; P:peptidoglycan biosynthetic process; IMP:EcoliWiki.
 GO:0008360; P:regulation of cell shape; IMP:EcoliWiki. 
Interpro
 IPR016169; CO_DH_flavot_FAD-bd_sub2.
 IPR016166; FAD-bd_2.
 IPR016167; FAD-bd_2_sub1.
 IPR003170; MurB.
 IPR011601; MurB_C.
 IPR006094; Oxid_FAD_bind_N. 
Pfam
 PF01565; FAD_binding_4
 PF02873; MurB_C 
SMART
  
PROSITE
 PS51387; FAD_PCMH 
PRINTS