UniProt Accession

 RL11_HUMAN; P62913; P25121; P39026; Q8TDH2; Q9Y674 

Genbank Protein ID

 X79234; L05092; AF101385; BC018970; AF432212; AB007171 

Genbank Nucleotide ID

 CAA55816.1; AAC15856.1; AAD20460.3; AAH18970.1; AAL99919.1; BAA25831.1 

Protein Name

 60S ribosomal protein L11 

Protein Synonyms/Alias

 CLL-associated antigen KW-12 

Gene Name

 RPL11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MADQGEKENPMREL	ubiquitination	[1, 2, 3]
37	DRLTRAAKVLEQLTG	ubiquitination	[4]
51	GQTPVFSKARYTVRS	ubiquitination	[4]
168	AMRWFQQKYDGIILP	ubiquitination	[4]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 44 44 Phosphothreonine.
 MOD_RES 52 52 N6-acetyllysine.
 MOD_RES 85 85 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Diamond-Blackfan anemia; Direct protein sequencing; Disease mutation; Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0034504; P:protein localization to nucleus; ISS:UniProtKB.
 GO:0042273; P:ribosomal large subunit biogenesis; IMP:UniProtKB.
 GO:0006364; P:rRNA processing; IMP:UniProtKB.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR002132; Ribosomal_L5.
 IPR020929; Ribosomal_L5_CS.
 IPR022803; Ribosomal_L5_domain. 

Pfam

 PF00281; Ribosomal_L5
 PF00673; Ribosomal_L5_C 

SMART

  

PROSITE

 PS00358; RIBOSOMAL_L5 

PRINTS