CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005982
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase PP2A regulatory subunit A 
Protein Synonyms/Alias
 PR65 
Gene Name
 TPD3 
Gene Synonyms/Alias
 YAL016W; FUN32 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
342DVREAVAKQVSGFAKubiquitination[1]
634AECQELLKN******ubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates. 
Sequence Annotation
 REPEAT 34 72 HEAT 1.
 REPEAT 73 111 HEAT 2.
 REPEAT 112 150 HEAT 3.
 REPEAT 151 189 HEAT 4.
 REPEAT 190 228 HEAT 5.
 REPEAT 229 273 HEAT 6.
 REPEAT 274 316 HEAT 7.
 REPEAT 317 356 HEAT 8.
 REPEAT 357 395 HEAT 9.
 REPEAT 396 434 HEAT 10.
 REPEAT 435 473 HEAT 11.
 REPEAT 474 512 HEAT 12.
 REPEAT 513 553 HEAT 13.
 REPEAT 554 598 HEAT 14.
 REPEAT 599 632 HEAT 15.  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 635 AA 
Protein Sequence
MSGARSTTAG AVPSAATTST TSTTSNSKDS DSNESLYPLA LLMDELKHDD IANRVEAMKK 60
LDTIALALGP ERTRNELIPF LTEVAQDDED EVFAVLAEQL GKFVPYIGGP QYATILLPVL 120
EILASAEETL VREKAVDSLN NVAQELSQEQ LFSDFVPLIE HLATADWFSS KVSACGLFKS 180
VIVRIKDDSL RKNILALYLQ LAQDDTPMVK RAVGKNLPIL IDLLTQNLGL STDEDWDYIS 240
NIFQKIINDN QDSVKFLAVD CLISILKFFN AKGDESHTQD LLNSAVKLIG DEAWRVRYMA 300
ADRFSDLASQ FSSNQAYIDE LVQPFLNLCE DNEGDVREAV AKQVSGFAKF LNDPSIILNK 360
ILPAVQNLSM DESETVRSAL ASKITNIVLL LNKDQVINNF LPILLNMLRD EFPDVRLNII 420
ASLKVVNDVI GIELLSDSLL PAITELAKDV NWRVRMAIIE YIPILAEQLG MQFFDQQLSD 480
LCLSWLWDTV YSIREAAVNN LKRLTEIFGS DWCRDEIISR LLKFDLQLLE NFVSRFTILS 540
ALTTLVPVVS LDVVTEQLLP FISHLADDGV PNIRFNVAKS YAVIVKVLIK DEAKYDALIK 600
NTILPSLQTL CQDEDVDVKY FAKKSLAECQ ELLKN 635 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000159; C:protein phosphatase type 2A complex; IDA:SGD.
 GO:0005816; C:spindle pole body; IDA:SGD.
 GO:0007094; P:mitotic spindle assembly checkpoint; IMP:SGD.
 GO:0006417; P:regulation of translation; IMP:SGD. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS