CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022315
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inositol monophosphatase 3 
Protein Synonyms/Alias
 IMP 3; IMPase 3; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident PAP phosphatase; gPAPP; Inositol monophosphatase domain-containing protein 1; Inositol-1(or 4)-monophosphatase 3; Myo-inositol monophosphatase A3 
Gene Name
 IMPAD1 
Gene Synonyms/Alias
 IMPA3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
156KIPEDILKEVTTPKEubiquitination[1]
282ALLDVPDKSQEKADLubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity). 
Sequence Annotation
 REGION 176 179 Substrate binding (By similarity).
 METAL 133 133 Magnesium 1 (By similarity).
 METAL 174 174 Magnesium 1 (By similarity).
 METAL 174 174 Magnesium 2 (By similarity).
 METAL 176 176 Magnesium 1; via carbonyl oxygen (By
 METAL 177 177 Magnesium 2 (By similarity).
 METAL 300 300 Magnesium 2 (By similarity).
 BINDING 133 133 Substrate (By similarity).
 BINDING 300 300 Substrate (By similarity).
 CARBOHYD 259 259 N-linked (GlcNAc...) (Probable).  
Keyword
 Complete proteome; Disease mutation; Glycoprotein; Golgi apparatus; Hydrolase; Magnesium; Membrane; Metal-binding; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MAPMGIRLSP LGVAVFCLLG LGVLYHLYSG FLAGRFSLFG LGGEPGGGAA GPAAAADGGT 60
VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL 120
LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ 180
EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPRIV 240
VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD 300
ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASIR MNHQALVRKL PDLEKTGHK 359 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008441; F:3'(2'),5'-bisphosphate nucleotidase activity; IEA:EC.
 GO:0008254; F:3'-nucleotidase activity; IEA:Compara.
 GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:EC.
 GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:EC.
 GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0002063; P:chondrocyte development; IEA:Compara.
 GO:0030204; P:chondroitin sulfate metabolic process; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0001958; P:endochondral ossification; IEA:Compara.
 GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.
 GO:0009791; P:post-embryonic development; IEA:Compara. 
Interpro
 IPR000760; Inositol_monophosphatase.
 IPR020550; Inositol_monophosphatase_CS. 
Pfam
 PF00459; Inositol_P 
SMART
  
PROSITE
 PS00629; IMP_1
 PS00630; IMP_2 
PRINTS