UniProt Accession

 S10A1_MOUSE; P56565; O88949 

Genbank Protein ID

 AA000715; AA207749; AA500563; AA432539; AF087687 

Genbank Nucleotide ID

 AAC64108.1 

Protein Name

 Protein S100-A1 

Protein Synonyms/Alias

 S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1 

Gene Name

 S100a1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
50	SGFLDVQKDADAVDK	ubiquitination	[1]
57	KDADAVDKVMKELDE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). 

Sequence Annotation

 DOMAIN 13 48 EF-hand 1.
 DOMAIN 50 85 EF-hand 2.
 MOD_RES 86 86 S-nitrosocysteine (By similarity).  

Keyword

 Calcium; Complete proteome; Cytoplasm; Metal-binding; Reference proteome; Repeat; S-nitrosylation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 94 AA 

Protein Sequence

Gene Ontology

 GO:0016529; C:sarcoplasmic reticulum; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR001751; S100/CaBP-9k_CS.
 IPR013787; S100_Ca-bd_sub. 

Pfam

 PF01023; S_100 

SMART

  

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00303; S100_CABP 

PRINTS