CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041318
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger CCCH domain-containing protein 14 
Protein Synonyms/Alias
  
Gene Name
 ZC3H14 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
139STSSQESKTTNVRQTubiquitination[1]
160TRLMSTVKPLREPAPubiquitination[2, 3]
175SEDVIDIKPEPDDLIubiquitination[2, 3]
245QNSIHAAKQLDMQSSubiquitination[1, 2, 4, 5]
283FFRNNSEKMSMEDENubiquitination[1, 2, 3, 5, 6]
295DENFRKRKLPVVSSVubiquitination[1]
306VSSVVKVKKFNHDGEubiquitination[1]
307SSVVKVKKFNHDGEEubiquitination[1, 2]
337SSVSVPAKPERRPSLubiquitination[1, 2]
352PPSKQANKNLILKAIubiquitination[1]
357ANKNLILKAISEAQEubiquitination[1, 2, 5]
368EAQESVTKTTNYSTVubiquitination[1, 2, 3, 4, 5]
378NYSTVPQKQTLPVAPubiquitination[1, 2, 3, 4, 5, 6]
413PRISPPIKEEETKGDubiquitination[1, 2]
418PIKEEETKGDSVEKNubiquitination[1]
424TKGDSVEKNQGTQQRubiquitination[2]
462SELSVAQKPEKLLERubiquitination[2, 3]
492HHPISPCKAFPNCKFubiquitination[1]
515PNCKYDAKCTKPDCPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED LSLFLGNNTI 60
RFTVWLHGVL DKLRSVTTEP SSLKSSDTNI FDSNVPSNKS NFSRGDERRH EAAVPPLAIP 120
SARPEKRDSR VSTSSQESKT TNVRQTYDDG AATRLMSTVK PLREPAPSED VIDIKPEPDD 180
LIDEDLNFVQ ENPLSQKKPT VTLTYGSSRP SIEIYRPPAS RNADSGVHLN RLQFQQQQNS 240
IHAAKQLDMQ SSWVYETGRL CEPEVLNSLE ETYSPFFRNN SEKMSMEDEN FRKRKLPVVS 300
SVVKVKKFNH DGEEEEEDDD YGSRTGSISS SVSVPAKPER RPSLPPSKQA NKNLILKAIS 360
EAQESVTKTT NYSTVPQKQT LPVAPRTRTS QEELLAEVVQ GQSRTPRISP PIKEEETKGD 420
SVEKNQGTQQ RQLLSRLQID PVMAETLQMS QAEMSELSVA QKPEKLLERC KYWPACKNGD 480
ECAYHHPISP CKAFPNCKFA EKCLFVHPNC KYDAKCTKPD CPFTHVSRRI PVLSPKPAVA 540
PPAPPSSSQL CRYFPACKKM ECPFYHPKHC RFNTQCTRPD CTFYHPTINV PPRHALKWIR 600
PQTSE 605 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR000571; Znf_CCCH. 
Pfam
  
SMART
 SM00356; ZnF_C3H1 
PROSITE
 PS50103; ZF_C3H1 
PRINTS