CPLM-002095

Genbank Nucleotide ID

Fatty acid-binding protein, adipocyte

Protein Synonyms/Alias

3T3-L1 lipid-binding protein; Adipocyte lipid-binding protein; ALBP; Adipocyte-type fatty acid-binding protein; A-FABP; AFABP; Fatty acid-binding protein 4; Myelin P2 protein homolog; P15; P2 adipocyte protein; Protein 422

Mus musculus (Mouse)

Position	Peptide	Type	References
10	DAFVGTWKLVSSENF	acetylation	[1]
22	ENFDDYMKEVGVGFA	acetylation	[1]
22	ENFDDYMKEVGVGFA	ubiquitination	[2]
32	GVGFATRKVAGMAKP	acetylation	[1]
32	GVGFATRKVAGMAKP	ubiquitination	[2]
38	RKVAGMAKPNMIISV	acetylation	[1]
38	RKVAGMAKPNMIISV	ubiquitination	[2]
59	IRSESTFKNTEISFK	acetylation	[1, 3, 4, 5]
59	IRSESTFKNTEISFK	ubiquitination	[2]
66	KNTEISFKLGVEFDE	acetylation	[1]
80	EITADDRKVKSIITL	acetylation	[1]
80	EITADDRKVKSIITL	ubiquitination	[2]
82	TADDRKVKSIITLDG	acetylation	[1]
97	GALVQVQKWDGKSTT	acetylation	[1]
97	GALVQVQKWDGKSTT	ubiquitination	[2]
101	QVQKWDGKSTTIKRK	acetylation	[1]
106	DGKSTTIKRKRDGDK	acetylation	[1]
108	KSTTIKRKRDGDKLV	acetylation	[1]
113	KRKRDGDKLVVECVM	acetylation	[1]
113	KRKRDGDKLVVECVM	ubiquitination	[2]
121	LVVECVMKGVTSTRV	acetylation	[1, 4, 5]
121	LVVECVMKGVTSTRV	ubiquitination	[2]

[1] Surface lysine residues modulate the collisional transfer of fatty acid from adipocyte fatty acid binding protein to membranes.
Herr FM, Matarese V, Bernlohr DA, Storch J.
Biochemistry. 1995 Sep 19;34(37):11840-5. [PMID: 7547918]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[3] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
[4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[5] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]

Functional Description

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

REGION 127 129 Fatty acid binding.
MOTIF 22 32 Nuclear localization signal.
MOD_RES 20 20 Phosphotyrosine; by Tyr-kinases (By

3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Nucleus; Phosphoprotein; Reference proteome; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0050873; P:brown fat cell differentiation; IDA:MGI.
GO:0071285; P:cellular response to lithium ion; IDA:MGI.
GO:0042632; P:cholesterol homeostasis; IMP:MGI.
GO:0001816; P:cytokine production; IMP:MGI.
GO:0006469; P:negative regulation of protein kinase activity; IMP:MGI.
GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:MGI.
GO:0050729; P:positive regulation of inflammatory response; IMP:MGI.
GO:0050872; P:white fat cell differentiation; IDA:MGI.

IPR012674; Calycin.
IPR011038; Calycin-like.
IPR000463; Fatty_acid-bd.
IPR000566; Lipocln_cytosolic_FA-bd_dom.

PR00178; FATTYACIDBP.